Evidence map›Paper›PMID 28861322›Full record

ArticleAmerican journal of cancer research2017

14-3-3ζ loss impedes oncogene-induced mammary tumorigenesis and metastasis by attenuating oncogenic signaling.

Sonali Joshi, Jun Yang, Qingfei Wang, Ping Li, Hai Wang, Qingling Zhang, Yan Xiong, Brian F Pickering, Jan Parker-Thornburg, Richard R Behringer and 1 more

Open access · greenAbstract read
In one paragraph

Article in American journal of cancer research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Review
  3. Experimental Study of Somatic Variants of Osteosarcoma by Whole-Exome Sequencing.Medical science monitor : international medical journal of experimental and clinical research · 2020
    Article
  4. Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 2 countries.

Sonali JoshiDepartment of Molecular & Cellular Oncology, The University of Texas MD Anderson Cancer CenterHouston, Texas 77030, USA.
Jun YangDepartment of Molecular & Cellular Oncology, The University of Texas MD Anderson Cancer CenterHouston, Texas 77030, USA.
Qingfei WangDepartment of Molecular & Cellular Oncology, The University of Texas MD Anderson Cancer CenterHouston, Texas 77030, USA.
Ping LiDepartment of Molecular & Cellular Oncology, The University of Texas MD Anderson Cancer CenterHouston, Texas 77030, USA.
Hai WangDepartment of Molecular & Cellular Oncology, The University of Texas MD Anderson Cancer CenterHouston, Texas 77030, USA.
Qingling ZhangDepartment of Molecular & Cellular Oncology, The University of Texas MD Anderson Cancer CenterHouston, Texas 77030, USA.
Yan XiongDepartment of Molecular & Cellular Oncology, The University of Texas MD Anderson Cancer CenterHouston, Texas 77030, USA.
Brian F PickeringDepartment of Molecular & Cellular Oncology, The University of Texas MD Anderson Cancer CenterHouston, Texas 77030, USA.
Jan Parker-ThornburgDepartment of Genetics, The University of Texas MD Anderson Cancer CenterHouston, Texas 77030, USA.
Richard R BehringerDepartment of Genetics, The University of Texas MD Anderson Cancer CenterHouston, Texas 77030, USA.
Dihua YuDepartment of Molecular & Cellular Oncology, The University of Texas MD Anderson Cancer CenterHouston, Texas 77030, USA.
The University of Texas MD Anderson Cancer Center · US

Funding

Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Scott Kopetz · 1985 to 2026
$290.8M
Tyrosine Kinase-Dependant and - Independent Pathways of EGFR in Breast Cancer ProP01CA099031 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI HUNG, MIEN-CHIE · 2003 to 2014
$11.6M
Stromal activation in the progression of high ErbB2/1433zeta DCIS to IBCR01CA112567 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI YU, DIHUA · 2005 to 2016
$3.0M
Target p70S6K for Chemodietary Prevention/Early Intervention of ER- Breast CancerR01CA184836 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI YU, DIHUA · 2015 to 2019
$1.8M
NCI NIH HHS P01 CA099031NCI NIH HHS P30 CA016672NCI NIH HHS R01 CA112567NCI NIH HHS R01 CA184836
6 · The paper itself

Abstract

The 14-3-3ζ protein belongs to the 14-3-3 family of regulatory eukaryotic proteins that modulate signaling by binding to wide variety of signaling molecules. 14-3-3ζ expression is amplified in over 40% breast cancer patients and is associated with a poor prognosis. Various

Indexed as

14-3-3ζmammary tumorsmetastasisoncogenic signaling

Identifiers

PMID28861322
PMCPMC5574938
OpenAlexW2755639184

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.