Evidence map›Paper›PMID 28861159›Full record

ArticleAmerican journal of translational research2017

Relationship and mechanism of Kv2.1 expression to ADH secretion in rats with heart failure.

Jiaxiang Li, Baiyun Tang, Wenbo Zhang, Cuiping Wang, Song Yang, Bao Zhang, Xiuren Gao

Open access · greenAbstract read
PubMed Full text at PMC
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Article in American journal of translational research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
0.4field-weighted citation impact, top 30% of its field
1 · What the graph read from it

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3 · Its place in the literature

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0 citing papers in PubMed, 2 citations in OpenAlex.

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4 · The record

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5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Jiaxiang LiDepartment of Cardiac Surgical Intensive Care Unit, First Affiliated Hospital, Sun Yat-sen UniversityGuangzhou, Guangdong, China.
Baiyun TangDepartment of Cardiac Surgical Intensive Care Unit, First Affiliated Hospital, Sun Yat-sen UniversityGuangzhou, Guangdong, China.
Wenbo ZhangDepartment of Cardiac Surgical Intensive Care Unit, First Affiliated Hospital, Sun Yat-sen UniversityGuangzhou, Guangdong, China.
Cuiping WangDepartment of Cardiac Surgical Intensive Care Unit, First Affiliated Hospital, Sun Yat-sen UniversityGuangzhou, Guangdong, China.
Song YangDepartment of Cardiac Surgical Intensive Care Unit, First Affiliated Hospital, Sun Yat-sen UniversityGuangzhou, Guangdong, China.
Bao ZhangDepartment of Cardiac Surgical Intensive Care Unit, First Affiliated Hospital, Sun Yat-sen UniversityGuangzhou, Guangdong, China.
Xiuren GaoDepartment of Cardiology, First Affiliated Hospital, Sun Yat-sen UniversityGuangzhou, Guangdong, China.
Sun Yat-sen University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo explore the mechanisms of Kv2.1 on the secretion of ADH in rats with heart failure.

methodsIn the animal study, 70 healthy male SD rats were selected. Ligation of coronary heart failure model surgery was performed in 60 rats and sham surgery was performed in the other 10 rats. Q-PCR was used to detect the mRNA expression of Kv2.1 in hypothalamus and heart. The protein expression of Kv2.1 and ADH was detected by western blot. In the cell culture study, hypothalamic neurons were cultured and divided into 7 groups. The mRNA expression of Kv2.1 and ADH was detected by Q-PCR. The protein expression of Kv2.1, CamKII, phosphorylation SynapsinI, dephosphorylation SynapsinI and ADH was detected by western blot.

resultsCompared with the control group of heart failure, LVEDD, LVESD, LVEDV and LVESV were significantly decreased (P < 0.01), and LVEF and LVFS were significantly increased (P < 0.01) in the Kv2.1 agonist group; in the Kv2.1 inhibitor group, LVEDD, LVESD, LVEDV and LVESV were significantly increased (P < 0.01), and LVEF and LVFS were significantly decreased (P < 0.01). In cell culture study, after the different concentrations of Kv2.1 inhibitor gradient down the expression of Kv2.1, intracellular Ca

conclusionsKv2.1 agonist can prevent the calcium overload by reducing the intracellular Ca

Indexed as

CaMKIIHeart failureKv2.1SynapsinIvasopressin

Identifiers

PMID28861159
PMCPMC5575182
OpenAlexW2996229953

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