ArticleAmerican journal of translational research2017
Calcitriol promotes survival of experimental random pattern flap via activation of autophagy.
Article in American journal of translational research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 20 citations in OpenAlex.
- Pharmacological and cell-based treatments to increase local skin flap viability in animal models.Journal of translational medicine · 2024Review
- Activities of (Poly)phenolic Antioxidants and Other Natural Autophagy Modulators in the Treatment of Sanfilippo Disease: Remarkable Efficacy of Resveratrol in Cellular and Animal Models.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2023Article
- Post-treatment with metformin improves random skin flap survival through promoting angiogenesis in rats.Veterinary research forum : an international quarterly journal · 2022Article
- Gastrodin Promotes the Survival of Random-Pattern Skin Flaps via Autophagy Flux Stimulation.Oxidative medicine and cellular longevity · 2021Article
- Curcumin promotes the survival of ischemic random skin flaps via autophagy.American journal of translational research · 2021Article
- Notoginseng Triterpenes Inhibited Autophagy in Random FlapsFrontiers in bioengineering and biotechnology · 2021Article
- Targeting TFE3 Protects Against Lysosomal Malfunction-Induced Pyroptosis in Random Skin Flaps via ROS Elimination.Frontiers in cell and developmental biology · 2021Article
- A Single, Acute Astragaloside IV Therapy Protects Cardiomyocyte Through Attenuating Superoxide Anion-Mediated Accumulation of Autophagosomes in Myocardial Ischemia-Reperfusion Injury.Frontiers in pharmacology · 2021Article
- Butylphthalide Inhibits Autophagy and Promotes Multiterritory Perforator Flap Survival.Frontiers in pharmacology · 2020Article
- Hydroxysafflor yellow A promotes multiterritory perforating flap survival: an experimental study.American journal of translational research · 2020Article
- Trehalose promotes the survival of random-pattern skin flaps by TFEB mediated autophagy enhancement.Cell death & disease · 2019Article
- Metformin Promotes the Survival of Random-Pattern Skin Flaps by Inducing Autophagy via the AMPK-mTOR-TFEB signaling pathway.International journal of biological sciences · 2019Article
- Effects of the traditional Chinese medicine baicalein on the viability of random pattern skin flaps in rats.Drug design, development and therapy · 2018Article
- Valproic acid enhances the viability of random pattern skin flaps: involvement of enhancing angiogenesis and inhibiting oxidative stress and apoptosis.Drug design, development and therapy · 2018Article
- Salvianolic Acid B Promotes the Survival of Random-Pattern Skin Flaps in Rats by Inducing Autophagy.Frontiers in pharmacology · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Calcitriol can promote random pattern flap survival and increase autophagy activity. However, effect of autophagy on flap survival after calcitriol treatment, along with the underlying mechanism, is undefined. In this study, the "McFarlane flap" model was established in 72 rats divided into control, calcitriol, and calcitriol+3-methyladenine (3MA) groups and injected with saline, calcitriol, and calcitriol plus 3MA, respectively. The percentage flap survival area and tissue water content were tested after 7 days. The extent of autophagy was evaluated by the expression of the autophagy markers LC3-II/I, Beclin1, and p62. Flap angiogenesis was assessed via hematoxylin and eosin (H&E) staining and immunohistochemistry (for CD34 levels). The level of vascular endothelial growth factor (VEGF) protein/mRNA was measured. Oxidative stress was assessed by measuring the activity of tissue superoxide dismutase (SOD) and the contents of glutathione (GSH) and malondialdehyde (MDA). Our results showed that 3MA decreased autophagy in random skin flap treated with calcitriol. Compared with the calcitriol group, the calcitriol+3MA group showed a smaller mean flap survival area and greater tissue edema, had a markedly decreased level of VEGF mRNA/protein and SOD activity, and a significantly higher level of MDA and GSH. H&E staining and immunohistochemistry showed that angiogenesis was inhibited in this group. In conclusion, calcitriol increased angiogenesis and reduced oxidative stress via activation of autophagy, contributing to a significant increase in random skin flap survival.
Indexed as
Identifiers
28861155PMC5575178W2952066333What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.