Evidence map›Paper›PMID 28861089›Full record

ArticleFrontiers in immunology2017

Black Raspberries Enhance Natural Killer Cell Infiltration into the Colon and Suppress the Progression of Colorectal Cancer.

Pan Pan, Siwen Kang, Youwei Wang, Ka Liu, Kiyoko Oshima, Yi-Wen Huang, Jianying Zhang, Martha Yearsley, Jianhua Yu, Li-Shu Wang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 45 citations in OpenAlex.

  1. Trial
  2. Article
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  6. Berries vs. Disease: Revenge of the Phytochemicals.Pharmaceuticals (Basel, Switzerland) · 2024
    Review
  7. Article
  8. Review
  9. [Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2022
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Pan PanDivision of Hematology and Oncology, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI, United States.
Siwen KangDivision of Hematology, Department of Internal Medicine, College of Medicine, The Ohio State University, Columbus, OH, United States.
Youwei WangDivision of Hematology, Department of Internal Medicine, College of Medicine, The Ohio State University, Columbus, OH, United States.
Ka LiuDivision of Hematology, Department of Internal Medicine, College of Medicine, The Ohio State University, Columbus, OH, United States.
Kiyoko OshimaDepartment of Pathology, Medical College of Wisconsin, Milwaukee, WI, United States.
Yi-Wen HuangDepartment of Obstetrics and Gynecology, Medical College of Wisconsin, Milwaukee, WI, United States.
Jianying ZhangCenter for Biostatistics, The Ohio State University, Columbus, OH, United States.
Martha YearsleyDepartment of Pathology, The Ohio State University, Columbus, OH, United States.
Jianhua YuDivision of Hematology, Department of Internal Medicine, College of Medicine, The Ohio State University, Columbus, OH, United States.
Li-Shu WangDivision of Hematology and Oncology, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI, United States.
The Ohio State University · USMedical College of Wisconsin · USThe Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute · US

Funding

Enhancing NK Cell Activity by Dietary Diphyllin Lignans for Cancer PreventionR01CA185301 · NCI · OHIO STATE UNIVERSITY · PI CALIGIURI, MICHAEL A, YU, JIANHUA · 2015 to 2019
$1.8M
Mechanisms of tumor suppressor gene reactivation in colon cancer by berriesR01CA148818 · NCI · OHIO STATE UNIVERSITY · PI WANG, LI-SHU · 2010 to 2014
$1.5M
NCI NIH HHS R01 CA148818NCI NIH HHS R01 CA185301
6 · The paper itself

Abstract

Natural killer (NK) cells are an essential component of innate immunity against cancer development. Many studies have been conducted to evaluate immune-modulating effects using dietary compounds. Our laboratory has been investigating the chemopreventive potential of black raspberries (BRBs) and previously demonstrated their beneficial modulation of genetic and epigenetic biomarkers in patients with colorectal cancer (CRC). The current study investigated their potential on modulating NK cells. To avoid the excessive inflammation caused by the dextran sulfate sodium (DSS) treatment that leads to colitis, we treated the mice with overnight DSS so that it would slightly irritate the colon but still promote colon carcinogenesis with 100% incidence in both the

Indexed as

ApcMin/+azoxymethaneblack raspberriescolorectal cancerdextran sulfate sodiumimmune surveillancenatural killer cells

Identifiers

PMID28861089
PMCPMC5561013
OpenAlexW2747265370

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.