ArticleFrontiers in neurology2017
Coding of Velocity Storage in the Vestibular Nuclei.
Article in Frontiers in neurology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04213079 (Treatments of Mal de Debarquement Syndrome), which is not on this map. Cited by 37 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Treatments of Mal de Debarquement Syndrome (MdDS) by Habituation of Velocity Storage
Who cites it
37 citing papers in PubMed.
- The acute, systemic effects of aerobic exercise in recently concussed adolescent student-athletes: preliminary findings.European journal of applied physiology · 2022Trial
- Gravity-Dependent Modulation of Downbeat Nystagmus: Insights From Velocity-Storage Dysfunction.Annals of clinical and translational neurology · 2026Article
- Persistent Dizziness and Time-Domain Dissociation in Vestibular Function: A Hypothesis-Generating Case Series and Spatiotemporal Framework for Targeted Vestibular Rehabilitation.Healthcare (Basel, Switzerland) · 2026Article
- Positional nystagmus in multiple sclerosis: a cross-sectional case-control study.BMC neurology · 2026Observational
- Visual and vestibular reweighting after cyber- and space-sickness.Experimental physiology · 2026Article
- Can video head impulse testing aid differential assessment of suspected vestibular migraine attacks?Frontiers in neurology · 2026Review
- Multidimensional Feature Analysis of Meniere's Disease and Vestibular Migraine: Insights from Machine Learning and Vestibular Testing.Journal of the Association for Research in Otolaryngology : JARO · 2025Article
- Skull vibration induced nystagmus, velocity storage and self-stability.Frontiers in neurology · 2025Article
- Horizontal head-shaking test: pathophysiological mechanisms and clinical interpretation.Frontiers in neurology · 2025Article
- Meclizine seasickness medication and its effect on central nervous system oxygen toxicity in a murine model.Diving and hyperbaric medicine · 2024Article
- A system of feed-forward cerebellar circuits that extend and diversify sensory signaling.eLife · 2024Article
- Cognition in vestibular disorders: state of the field, challenges, and priorities for the future.Frontiers in neurology · 2024Review
- On labyrinthine function loss, motion sickness immunity, and velocity storage.Frontiers in neurology · 2024Article
- Vestibulo-spatial navigation: pathways and sense of direction.Journal of neurophysiology · 2023Article
- Emerging order of anomalous eye movements with progressive drowsiness.Journal of vision · 2023Article
- Imbalance and dizziness caused by unilateral vestibular schwannomas correlate with vestibulo-ocular reflex precision and bias.Journal of neurophysiology · 2022Article
- Treatment of Gravitational Pulling Sensation in Patients With Mal de Debarquement Syndrome (MdDS): A Model-Based Approach.Frontiers in integrative neuroscience · 2022Article
- Reduced Gain and Shortened Time Constant of Vestibular Velocity Storage as a Source of Balance and Movement Sensitivities in Gravitational Insecurity.Occupational therapy international · 2022Article
- A New Vestibular Stimulation Mode for Motion Sickness With Emphatic Analysis of Pica.Frontiers in behavioral neuroscience · 2022Article
- The otolith vermis: A systems neuroscience theory of the Nodulus and Uvula.Frontiers in systems neuroscience · 2022Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Semicircular canal afferents sense angular acceleration and output angular velocity with a short time constant of ≈4.5 s. This output is prolonged by a central integrative network, velocity storage that lengthens the time constants of eye velocity. This mechanism utilizes canal, otolith, and visual (optokinetic) information to align the axis of eye velocity toward the spatial vertical when head orientation is off-vertical axis. Previous studies indicated that vestibular-only (VO) and vestibular-pause-saccade (VPS) neurons located in the medial and superior vestibular nucleus could code all aspects of velocity storage. A recently developed technique enabled prolonged recording while animals were rotated and received optokinetic stimulation about a spatial vertical axis while upright, side-down, prone, and supine. Firing rates of 33 VO and 8 VPS neurons were studied in alert cynomolgus monkeys. Majority VO neurons were closely correlated with the horizontal component of velocity storage in head coordinates, regardless of head orientation in space. Approximately, half of all tested neurons (46%) code horizontal component of velocity in head coordinates, while the other half (54%) changed their firing rates as the head was oriented relative to the spatial vertical, coding the horizontal component of eye velocity in spatial coordinates. Some VO neurons only coded the cross-coupled pitch or roll components that move the axis of eye rotation toward the spatial vertical. Sixty-five percent of these VO and VPS neurons were more sensitive to rotation in one direction (predominantly contralateral), providing directional orientation for the subset of VO neurons on either side of the brainstem. This indicates that the three-dimensional velocity storage integrator is composed of directional subsets of neurons that are likely to be the bases for the spatial characteristics of velocity storage. Most VPS neurons ceased firing during drowsiness, but the firing rates of VO neurons were unaffected by states of alertness and declined with the time constant of velocity storage. Thus, the VO neurons are the prime components of the mechanism of coding for velocity storage, whereas the VPS neurons are likely to provide the path from the vestibular to the oculomotor system for the VO neurons.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.