Evidence map›Paper›PMID 28860990›Full record

ArticleFrontiers in pharmacology2017

Anaplastic Lymphoma Kinase Is a Regulator of Alcohol Consumption and Excitatory Synaptic Plasticity in the Nucleus Accumbens Shell.

Regina A Mangieri, Esther Y Maier, Tavanna R Buske, Amy W Lasek, Richard A Morrisett

Open access · goldAbstract read
In one paragraph

Article in Frontiers in pharmacology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.4field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 24 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Alcohol and the brain: from genes to circuits.Trends in neurosciences · 2021
    Review
  6. Article
  7. Growth Factors and Alcohol Use Disorder.Cold Spring Harbor perspectives in medicine · 2020
    Review
  8. Article
  9. Receptor Tyrosine Kinases as Therapeutic Targets for Alcohol Use Disorder.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2020
    Review
  10. Article
  11. Article
  12. Review
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Regina A MangieriDivision of Pharmacology and Toxicology, College of Pharmacy, The University of Texas at Austin, AustinTX, United States.
Esther Y MaierDivision of Pharmacology and Toxicology, College of Pharmacy, The University of Texas at Austin, AustinTX, United States.
Tavanna R BuskeDivision of Pharmacology and Toxicology, College of Pharmacy, The University of Texas at Austin, AustinTX, United States.
Amy W LasekDepartment of Psychiatry, University of Illinois at Chicago, ChicagoIL, United States.
Richard A MorrisettDivision of Pharmacology and Toxicology, College of Pharmacy, The University of Texas at Austin, AustinTX, United States.
The University of Texas at Austin · USUniversity of Illinois Chicago · US

Funding

Regulation of Excessive Alcohol Consumption by the Lmo-Alk AxisU01AA020912 · NIAAA · VIRGINIA COMMONWEALTH UNIVERSITY · PI Amy Wolven Lasek · 2011 to 2026
$5.4M
Target Validation byAccumbal Plasticity ScreeningU01AA016651 · NIAAA · UNIVERSITY OF TEXAS AT AUSTIN · PI Regina A. Mangieri · 2006 to 2026
$3.8M
Ethanol, Dependence and Mesolimbic PlasticityR01AA015167 · NIAAA · UNIVERSITY OF TEXAS AUSTIN · PI MANGIERI, REGINA A. · 2005 to 2015
$2.3M
Target Validation Electrophysiology CoreU24AA016651 · NIAAA · UNIVERSITY OF TEXAS AT AUSTIN · PI MANGIERI, REGINA A. · 2015 to 2021
$1.7M
NIAAA NIH HHS R01 AA015167NIAAA NIH HHS U01 AA016651NIAAA NIH HHS U01 AA020912NIAAA NIH HHS U24 AA016651
6 · The paper itself

Abstract

Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase recently implicated in biochemical, physiological, and behavioral responses to ethanol. Thus, manipulation of ALK signaling may represent a novel approach to treating alcohol use disorder (AUD). Ethanol induces adaptations in glutamatergic synapses onto nucleus accumbens shell (NAcSh) medium spiny neurons (MSNs), and putative targets for treating AUD may be validated for further development by assessing how their manipulation modulates accumbal glutamatergic synaptic transmission and plasticity. Here, we report that

Indexed as

electrophysiologyglutamatemiceoperant self-administrationtwo-bottle choice

Identifiers

PMID28860990
PMCPMC5559467
OpenAlexW2748819228

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.