Evidence map›Paper›PMID 28860955›Full record

ArticleImmune network2017

Localization of Serum Amyloid A3 in the Mouse Ovary.

Hyeongjwa Choi, Rosa Mistica C Ignacio, Eun-Sook Lee, Katherine F Roby, Paul F Terranova, Deok-Soo Son

Open access · hybridAbstract read
In one paragraph

Article in Immune network, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Hyeongjwa ChoiDepartment of Biochemistry and Cancer Biology, Meharry Medical College, Nashville, TN 37208, USA.
Rosa Mistica C IgnacioDepartment of Biochemistry and Cancer Biology, Meharry Medical College, Nashville, TN 37208, USA.
Eun-Sook LeeDepartment of Pharmaceutical Sciences, College of Pharmacy, Florida A&M University, Tallahassee, FL 32301, USA.
Katherine F RobyCenter for Reproductive Sciences, University of Kansas Medical Center, Kansas City, KS 66160, USA.
Paul F TerranovaCenter for Reproductive Sciences, University of Kansas Medical Center, Kansas City, KS 66160, USA.
Deok-Soo SonDepartment of Biochemistry and Cancer Biology, Meharry Medical College, Nashville, TN 37208, USA.
Meharry Medical College · USUniversity of Kansas Medical Center · USFlorida Agricultural and Mechanical University · US

Funding

The RCMI Program in Health Disparities Research at Meharry Medical College - SupplementU54MD007586 · NIMHD · MEHARRY MEDICAL COLLEGE · PI Maureen Sanderson · 2017 to 2026
$48.2M
Translational Pathology CoreU54CA163069 · NCI · MEHARRY MEDICAL COLLEGE · PI ADUNYAH, SAMUEL EVANS · 2011 to 2025
$18.8M
Meharry RCMI Program in Women's Health ResearchG12MD007586 · NIMHD · MEHARRY MEDICAL COLLEGE · PI HILDRETH, JAMES E · 2012 to 2016
$7.8M
Mechanism of manganese-induced impairment of astrocytic glutamate transportersR01ES024756 · NIEHS · MEHARRY MEDICAL COLLEGE · PI LEE, EUN SOOK YU · 2015 to 2019
$1.8M
Roles of inflammation-driven chemokines in the pathogenesis of ovarian cancerSC1AI089073 · NIAID · MEHARRY MEDICAL COLLEGE · PI SON, DEOK-SOO · 2009 to 2013
$1.8M
Roles of proinflammatory chemokines linking obesity and breast cancerSC1CA200519 · NCI · MEHARRY MEDICAL COLLEGE · PI SON, DEOK-SOO · 2015 to 2018
$1.5M
Estrogen-neuroprotection due to astroglial Glu transporters occurs via TGF-a/b1SC1GM089630 · NIGMS · MEHARRY MEDICAL COLLEGE · PI LEE, EUN SOOK YU · 2010 to 2014
$1.4M
NCI NIH HHS SC1 CA200519NCI NIH HHS U54 CA163069NIAID NIH HHS SC1 AI089073NIEHS NIH HHS R01 ES024756NIGMS NIH HHS SC1 GM089630NIMHD NIH HHS G12 MD007586
6 · The paper itself

Abstract

Tumor necrosis factor-α (TNF-α) induces serum amyloid A (SAA) 3 among acute-phase proteins in mouse granulosa cells by activating NF-κB signaling via p55 TNF-α receptor type 1. However, the localization of SAA3 within the ovary is unknown. Here we investigated ovarian localization of SAA3 in a mouse ovulation model and in response to IL-1β, a proinflammatory mediator. For the ovulation model, equine chorionic gonadotropin (eCG; 2.5 IU) was administered to mice subcutaneously (sc) to stimulate follicular development on day 25 of age and then 50 h after eCG, human chorionic gonadotropin (hCG; 2.5 IU) was administered sc to induce ovulation. The mouse ovulation model was characterized by the localization of CYP19 mRNA expression to granulosa layers of larger follicles. SAA3 mRNA, determined by

Indexed as

OvaryOvulationSerum amyloid A

Identifiers

PMID28860955
PMCPMC5577303
OpenAlexW2751049390

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.