Evidence map›Paper›PMID 28860941›Full record

ArticleCentral-European journal of immunology2017

Dengue virus and Japanese encephalitis virus infection of the central nervous system share similar profiles of cytokine accumulation in cerebrospinal fluid.

Haipeng Li, Yuanyuan Li, Bo Wen, Jian Zhang, Chengwu Wang, Zhanyi Song, Shuochi Li, Xiaowang Qu, Renbin Huang, Wenpei Liu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Central-European journal of immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.

  1. Pooled it
  2. Metabolic response to CNS infection with flaviviruses.Journal of neuroinflammation · 2023
    Review
  3. Article
  4. [Influence of coronavirus disease 2019 on the nervous system of children].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2021
    Review
  5. Article
  6. Article
  7. Endothelins in inflammatory neurological diseases.Pharmacology & therapeutics · 2019
    Review
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Haipeng LiTranslational Medicine Institute, The First People's Hospital of Chenzhou, University of South China, Chenzhou, Hunan, China.
Yuanyuan LiTranslational Medicine Institute, The First People's Hospital of Chenzhou, University of South China, Chenzhou, Hunan, China.
Bo WenTranslational Medicine Institute, The First People's Hospital of Chenzhou, University of South China, Chenzhou, Hunan, China.
Jian ZhangTranslational Medicine Institute, The First People's Hospital of Chenzhou, University of South China, Chenzhou, Hunan, China.
Chengwu WangTranslational Medicine Institute, The First People's Hospital of Chenzhou, University of South China, Chenzhou, Hunan, China.
Zhanyi SongTranslational Medicine Institute, The First People's Hospital of Chenzhou, University of South China, Chenzhou, Hunan, China.
Shuochi LiTranslational Medicine Institute, The First People's Hospital of Chenzhou, University of South China, Chenzhou, Hunan, China.
Xiaowang QuTranslational Medicine Institute, The First People's Hospital of Chenzhou, University of South China, Chenzhou, Hunan, China.
Renbin HuangTranslational Medicine Institute, The First People's Hospital of Chenzhou, University of South China, Chenzhou, Hunan, China.
Wenpei LiuTranslational Medicine Institute, The First People's Hospital of Chenzhou, University of South China, Chenzhou, Hunan, China.
University of South China · CNChenzhou First People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dengue virus (DENV) and Japanese encephalitis virus (JEV) are two important pathogenic viruses that can cause severe encephalitis, which is accompanied by inflammatory cytokines. However, the inflammatory cytokine content of cerebrospinal fluid (CSF) in DENV and JEV infection of central nervous system are not sufficiently studied. To investigate cytokine levels in serum and CSF of hospitalised children with DENV and JEV infection of the central nervous system, a total of 183 hospitalised children with viral encephalitis-like syndrome were enrolled between May 2014 and April 2015 at the Children's Hospital of Chenzhou, Hunan, China. DENV and JEV infection was diagnosed by ELISA. Cytokine levels in the serum and CSF were measured by commercial ELISA kits. Twenty-nine (15.85%) and 26 (14.21%) DENV and JEV infections were detected in 183 patients with viral encephalitis-like syndrome, respectively. Higher granulocyte-macrophage colony-stimulating factor (GM-CSF) levels were detected in the serum of JEV infected patients than in DNEV patients (p < 0.05) or in healthy controls (p < 0.001), and levels of GM-CSF, interleukin 6 (IL-6) and monocyte chemoattractant protein-1 (MCP-1) were higher in the CSF than serum in both DENV and JEV infection. Both DENV and JEV infection induced similar cytokine accumulation profiles in the CSF, which probably contributed to DENV- and JEV-induced immunopathogenesis.

Indexed as

central nervous systemcytokinedengue virusJapanese encephalitis virus

Identifiers

PMID28860941
PMCPMC5573897
OpenAlexW2743008528

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.