ArticleCentral-European journal of immunology2017
Common variants in IL-1RN, IL-1β and TNF-α and the risk of ovarian cancer: a case control study.
Article in Central-European journal of immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 25 citations in OpenAlex.
- Comparative Effects of Pairwise Combinations of Carboplatin, Everolimus, and Astaxanthin on Cell Viability, Migration, and Inflammatory Biomarkers in SKOV3 Ovarian Cancer Cells.International journal of molecular sciences · 2026Article
- A machine learning approach to a nine-SNP immunogenetic score for prognostic stratification in cervical cancer.Frontiers in immunology · 2026Article
- Article
- Epigenetics of Thymic Epithelial Tumors.Cancers · 2023Review
- Decreased risk of ovarian cancer associated with rs9898876 sex hormone-binding globulin gene variant.Molecular biology reports · 2022Article
- Prolactin and Risk of Epithelial Ovarian Cancer.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2021Article
- Review
- First insights into the molecular basis association between promoter polymorphisms of the IL1B gene and Helicobacter pylori infection in the Sudanese population: computational approach.BMC microbiology · 2021Article
- Interleukin-1β and Cancer.Cancers · 2020Review
- Thrombocytopenia in solid tumors: Prognostic significance.Oncology reviews · 2019Article
- The Role of Interleukin-1 in the Pathogenesis of Cancer and its Potential as a Therapeutic Target in Clinical Practice.Oncology and therapy · 2018Review
- The Genetic Polymorphisms of NLRP3 Inflammasome Associated with T Helper Cells in Patients with Multiple Myeloma.Journal of immunology research · 2018Article
- Allergy-Related Diseases and Risk of Breast Cancer: The Role of Skewed Immune System on This Association.Allergy & rhinology (Providence, R.I.)Review
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aim of the studySeveral studies implicated altered inflammatory response in the susceptibility to ovarian cancer, and polymorphisms in inflammatory cytokines were shown to play an important role in the development of malignancies, including ovarian cancer (OC). Here we investigated the relationship between polymorphisms in IL-1 METHODS AND
resultsStudy subjects comprised 62 OC patients and 126 healthy women. Genotyping was done from genomic DNA obtained from blood simple by PCR. Positive association between IL-1RN (-VNTR) A1 allele (p = 0.0069; OR = 2.04; 95% CI:1.17-3.58) and OC risk, while negative association was seen with the A3 allele (P = 0.0034; OR = 0.09; 95% CI: 0.00-0.64), suggesting a protective role by the A3 allele. For IL-1
conclusionsThe significant association between IL-1RN VNTR, IL1-
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