ArticleDrug, healthcare and patient safety2017
Early rehospitalizations of frail elderly patients - the role of medications: a clinical, prospective, observational trial.
Article in Drug, healthcare and patient safety, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Prevalence of and Risk Factors for Drug-Related Readmissions in Older Adults: A Systematic Review and Meta-Analysis.Drugs & aging · 2024Pooled it
- The Relationship between Anaemia and Frailty: A Systematic Review and Meta-Analysis of Observational Studies.The journal of nutrition, health & aging · 2018Pooled it
- Article
- Avoiding Escalation to the Emergency Department by Activating an In-Home Rapid Response Team in the 30 Days After Hospital-at-Home Discharge.The Journal of emergency medicine · 2023Article
- Article
- Scoping Review of Studies Evaluating Frailty and Its Association with Medication Harm.Drugs & aging · 2022Article
- Obstacles and Opportunities in Information Transfer Regarding Medications at Discharge - A Focus Group Study with Hospital Physicians.Drug, healthcare and patient safety · 2022Article
- Effect of Anemia on Readmission and Death in Octogenarian Patients with Lower Respiratory Tract Infections: A Retrospective Cohort Study.International journal of clinical practice · 2022Article
- Prevalence of frailty and associated factors among Saudi community-dwelling older adults: a cross-sectional study.BMC geriatrics · 2021Article
- Risk factors for hospital readmission in older adults within 30 days of discharge - a comparative retrospective study.BMC geriatrics · 2020Article
- Changes in Treatment of Very Elderly Patients Six Weeks after Discharge from Geriatrics Department.Geriatrics (Basel, Switzerland) · 2020Article
- Patient safety in marginalised groups: a narrative scoping review.International journal for equity in health · 2020Article
- Hospitalized frail elderly patients - atrial fibrillation, anticoagulation and 12 months' outcomes.Clinical interventions in aging · 2018Observational
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectiveEarly readmissions of frail elderly patients after an episode of hospital care are common and constitute a crucial patient safety outcome. Our purpose was to study the impact of medications on such early rehospitalizations. PATIENTS AND
methodsThis is a clinical, prospective, observational study on rehospitalizations within 30 days after an acute hospital episode for frail patients over the age of 75 years. To identify adverse drug reactions (ADRs), underuse of evidence-based treatment and avoidability of rehospitalizations, the Naranjo score, the Hallas criteria and clinical judgment were used.
resultsOf 390 evaluable patients, 96 (24.6%) were rehospitalized. The most frequent symptoms and conditions were dyspnea (n = 25) and worsened general condition (n = 18). The most frequent diagnoses were heart failure (n = 17) and pneumonia/acute bronchitis (n = 13). By logistic regression analysis, independent risk predictors for rehospitalization were heart failure (odds ratio [OR] = 1.8; 95% CI = 1.1-3.1) and anemia (OR = 2.3; 95% CI = 1.3-4.0). The number of rehospitalizations due to probable ADRs was 13, of which two were assessed as avoidable. The number of rehospitalizations probably due to underuse of evidence-based drug treatment was 19, all of which were assessed as avoidable. The number of rehospitalizations not due to ADRs or underuse of evidence-based drug treatment was 64, of which none was assessed as avoidable.
conclusionOne out of four frail elderly patients discharged from hospital was rehospitalized within 1 month. Although ADRs constituted an important cause of rehospitalization, underuse of evidence-based drug treatment might be an even more frequent cause. Potentially avoidable rehospitalizations were more frequently associated with underuse of evidence-based drug treatment than with ADRs. Efforts to avoid ADRs in frail elderly patients must be balanced and combined with evidence-based drug therapy, which can benefit these patients.
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