Evidence map›Paper›PMID 28860814›Full record

ReviewOncoTargets and therapy2017

The role of desmosomes in carcinogenesis.

Guangxin Zhou, Linlin Yang, Ashley Gray, Amit Kumar Srivastava, Cuiping Li, Gongwen Zhang, Tiantian Cui

Abstract readReview
In one paragraph

Review in OncoTargets and therapy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed.

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  10. Identification of a Novel miR-195-5p/PNN Axis in Colorectal Cancer.International journal of molecular sciences · 2024
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  17. Genetic predisposition study of heart failure and its association with cardiomyopathy.The Egyptian heart journal : (EHJ) : official bulletin of the Egyptian Society of Cardiology · 2022
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Guangxin ZhouDepartment of Oncology, Central Hospital of Binzhou, Binzhou Medical College, Binzhou, People's Republic of China.
Linlin YangDepartment of Radiation Oncology, Arthur G James Hospital/Ohio State Comprehensive Cancer Center.
Ashley GrayThe Ohio State University.
Amit Kumar SrivastavaDivision of Radiobiology, Department of Radiology, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
Cuiping LiDepartment of Respiratory Medicine.
Gongwen ZhangDepartment of Cardiac Surgery, Central Hospital of Binzhou, Binzhou Medical College, Binzhou, People's Republic of China.
Tiantian CuiDepartment of Radiation Oncology, Arthur G James Hospital/Ohio State Comprehensive Cancer Center.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Desmosomes, which are intercellular adhesive complexes, are essential for the maintenance of epithelial homeostasis. They are located at the cell membrane, where they act as anchors for intermediate filaments. Downregulation of desmosome proteins in various cancers promotes tumor progression. However, the role of desmosomes in carcinogenesis is still being elucidated. Recent studies revealed that desmosome family members play a crucial role in tumor suppression or tumor promotion. This review focuses on studies that provide insights into the role of desmosomes in carcinogenesis and address their molecular functions.

Indexed as

desmoplakindesmosomal cadherindesmosomeplakoglobinplakophilinsβ-catenin

Identifiers

PMID28860814
PMCPMC5565390

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.