Evidence map›Paper›PMID 28860812›Full record

ArticleOncoTargets and therapy2017

An integrated analysis for long noncoding RNAs and microRNAs with the mediated competing endogenous RNA network in papillary renal cell carcinoma.

Chuiguo Huang, Naijun Yuan, Liying Wu, Xiaofu Wang, Junqiang Dai, Pan Song, Fengxi Li, Changbao Xu, Xinghua Zhao

Open access · goldAbstract read
In one paragraph

Article in OncoTargets and therapy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 36 citations in OpenAlex.

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  10. [Comprehensive analysis of the aberrantly expressed profiles of lncRNAs, miRNAs and the regulation network of the associated ceRNAs in clear cell renal cell carcinoma].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2019
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 1 country.

Chuiguo HuangDepartment of Urology, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou.
Naijun YuanCollege of Traditional Chinese Medicine of Jinan University, Institute of Integrated Traditional Chinese and Western Medicine of Jinan University, Guangzhou.
Liying WuDepartment of Nephrology, The Second Affiliated Hospital of Hainan Medical College, Hainan.
Xiaofu WangDepartment of Urology, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou.
Junqiang DaiDepartment of Neurosurgery, The Second Affiliated Hospital of Lanzhou University, Lanzhou.
Pan SongDepartment of Urology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou.
Fengxi LiDepartment of General Surgery, The First Affiliated Hospital of Guangxi Medical University, Guangxi, People's Republic of China.
Changbao XuDepartment of Urology, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou.
Xinghua ZhaoDepartment of Urology, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou.
Second Affiliated Hospital of Zhengzhou University · CNFirst Affiliated Hospital of GuangXi Medical University · CNFirst Affiliated Hospital of Zhengzhou University · CNHainan Medical College Hospital · CNLanzhou University Second Hospital · CNShandong University of Traditional Chinese Medicine · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Papillary renal cell carcinoma (PRCC) is the second most common subtype of renal cell carcinoma, and it lacks effective therapeutic targets and prognostic molecular biomarkers. Attention has been increasingly focused on long noncoding RNAs (lncRNAs), which can act as competing endogenous RNA (ceRNA) to compete for shared microRNAs (miRNAs) in the tumorigenesis of human tumors. Therefore, to clarify the functional roles of lncRNAs with respect to the mediated ceRNA network in PRCC, we comprehensively integrated expression profiles, including data on mRNAs, lncRNAs and miRNAs obtained from 289 PRCC tissues and 32 normal tissues in The Cancer Genome Atlas. As a result, we identified 2,197 differentially expressed mRNAs (DEmRNAs) and 84 differentially expressed miRNAs (DEmiRNAs) using a threshold of |log2 (fold change)| >2.0 and an adjusted

Indexed as

competing endogenous RNA networklong noncoding RNApapillary renal cell carcinomasurvival prognosisThe Cancer Genome Atlasweighted gene co-expression network analysis

Identifiers

PMID28860812
PMCPMC5565391
OpenAlexW2747781382

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.