ArticleNeuropsychiatric disease and treatment2017
Factors associated with failure to achieve remission and with relapse after remission in patients with major depressive disorder in the PERFORM study.
Article in Neuropsychiatric disease and treatment, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
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Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it, 61 citations in OpenAlex.
- Is the antidepressant efficacy of ketamine and esketamine mediated via opioid mechanisms?European psychiatry : the journal of the Association of European Psychiatrists · 2026Pooled it
- A Randomized Controlled Study of Efficacy and Cognitive Function Improvement of Vortioxetine and Escitalopram in Patients with Depression in Chinese Han Nationality.Neuropsychiatric disease and treatment · 2024Trial
- Changes in brain functional networks in remitted major depressive disorder: a six-month follow-up study.BMC psychiatry · 2023Trial
- Optimization of Levomilnacipran Loaded Nanostructured Lipid Carrier Using Response Surface Methodology.Pharmaceutical nanotechnology · 2026Article
- Trend analysis of antidepressant consumption in Italy from 2008 to 2022 in a public health perspective.Scientific reports · 2025Article
- Therapeutic Approaches to Tackle the Challenge of Depression That Is Resistant to Treatment-A Narrative Review.Health science reports · 2025Article
- Impact of Emotional Blunting on Patient Social Function and Depressive Symptoms: A Post Hoc Analysis of a Web-Based Survey in Japanese Patients with Major Depressive Disorder.Neuropsychiatric disease and treatment · 2025Article
- Disproportionality evaluation of adverse effects and suicide/self-injury risk factors associated with vortioxetine: a large-scale pharmacovigilance study.Frontiers in pharmacology · 2025Article
- Verbal memory in major depressive disorder in a long-term perspective: a five-year longitudinal study of first episode patients.Frontiers in psychiatry · 2025Article
- In-person psychoeducational intervention to reduce rehospitalizations and improve the clinical course of major depressive disorder: a non-randomized pilot study.Frontiers in psychiatry · 2024Article
- Hippocampal and parahippocampal volume and function predict antidepressant response in patients with major depression: A multimodal neuroimaging study.Journal of psychopharmacology (Oxford, England) · 2023Article
- Improvement in self-reported cognitive functioning but not in rumination following online working memory training in a two-year follow-up study of remitted major depressive disorder.Frontiers in psychiatry · 2023Article
- The Use of Psychotropic Medication in Pediatric Oncology for Acute Psychological and Psychiatric Problems: Balancing Risks and Benefits.Children (Basel, Switzerland) · 2022Review
- Article
- Cognitive Impairment and Neurocognitive Profiles in Major Depression-A Clinical Perspective.Frontiers in psychiatry · 2022Review
- Identifying factors associated with the hospital readmission rate among patients with major depressive disorder.BMC psychiatry · 2021Article
- Toward an Extended Definition of Major Depressive Disorder Symptomatology: Digital Assessment and Cross-validation Study.JMIR formative research · 2021Article
- Goal Management Training and Computerized Cognitive Training in Depression-a 2-Year Follow-Up of a Randomized Controlled Trial.Frontiers in psychiatry · 2021Article
- Patient Expectations and Experiences of Antidepressant Therapy for Major Depressive Disorder: A Qualitative Study.Neuropsychiatric disease and treatment · 2021Article
- Patient and Physician Perspectives of Depressive Symptoms and Expectations for Treatment Outcome: Results from a Web-Based Survey.Neuropsychiatric disease and treatment · 2021Article
Corrections and comments
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Authors and funding
9 authors at 7 institutions in 6 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe Prospective Epidemiological Research on Functioning Outcomes Related to Major Depressive Disorder (PERFORM) study has been initiated to better understand the course of a depressive episode and its impact on patient functioning. This analysis aimed to identify sociodemographic and clinical factors associated with failure to achieve remission at month 2 after initiating or switching antidepressant monotherapy and with subsequent relapse at month 6 for patients in remission at month 2. MATERIALS AND
methodsThis was a 2-year observational cohort study in 1,159 outpatients aged 18-65 years with major depressive disorder initiating or undergoing the first switch of antidepressant monotherapy. Factors with
resultsBaseline factors significantly associated with lower odds of remission at month 2 were body-mass index ≥30 kg/m
conclusionDifferent factors appear to be associated with failure to achieve remission in patients with major depressive disorder and with subsequent relapse in patients who do achieve remission. Patient-reported cognitive dysfunction is an easily measurable and treatable characteristic that may be associated with an increased likelihood of relapse at 6 months in patients who have achieved remission.
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