Evidence map›Paper›PMID 28860770›Full record

ArticleNeuropsychiatric disease and treatment2017

Early predictors of brain damage in full-term newborns with hypoxic ischemic encephalopathy.

Usama M Alkholy, Nermin Abdalmonem, Ahmed Zaki, Yasser F Ali, Soma Abdalla Mohamed, Nasser I Abdelsalam, Mustafa Ismail Abu Hashim, Mohamed Abou Sekkien, Yasser Makram Elsherbiny

Erratum issuedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuropsychiatric disease and treatment, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Usama M AlkholyPediatric Department, Zagazig University, Egypt.
Nermin AbdalmonemPediatric Department, Zagazig University, Egypt.
Ahmed ZakiPediatric Department, Mansoura University, Egypt.
Yasser F AliPediatric Department, Zagazig University, Egypt.
Soma Abdalla MohamedPediatric Department, Al Azhar University, Egypt.
Nasser I AbdelsalamPediatric Department, Zagazig University, Egypt.
Mustafa Ismail Abu HashimPediatric Department, Zagazig University, Egypt.
Mohamed Abou SekkienPediatric Department, Al Azhar University, Egypt.
Yasser Makram ElsherbinyClinical Pathology Department, Menoufia University, Egypt.
Zagazig University · EGAl-Azhar University · EGMansoura University · EGMenoufia University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objective of the studyTo evaluate the value of serum creatine phosphokinase-brain specific (CK-BB) and urinary lactate/creatinine (L/C) ratio as early indicators of brain damage in full-term newborns with hypoxic ischemic encephalopathy (HIE). PATIENTS AND

methodsA case-control study including 25 full-term new-born infants with perinatal asphyxia who were admitted to neonatal intensive care unit (NICU) with a proven diagnosis of HIE, compared to 20 healthy age- and sex-matched full-term newborns. All newborn infants were subjected to full history taking, clinical examination, routine investigations (cord blood gases and complete blood picture), and assessment of serum CK-BB (cord blood, 6 and 24 hours after birth) and urinary L/C ratio (collected within the first 6 hours, on the 2nd and 3rd day after birth).

resultsThe serum CK-BB and urinary L/C ratio in infants with HIE were significantly higher in samples collected throughout the monitoring period when compared with the control group (all

conclusionThe serum CK-BB and urinary L/C ratio in HIE infants were significantly increased early in the course of the disease, which can be used as useful indicators for predicting the development of HIE.

Indexed as

biomarkershypoxic ischemic encephalopathyneonatal morbidityserum CKBBurinary lactate

Identifiers

PMID28860770
PMCPMC5558899
OpenAlexW2743388901

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.