ArticleClinical ophthalmology (Auckland, N.Z.)2017
Alteration of retinal layers in healthy subjects over 60 years of age until nonagenarians.
Article in Clinical ophthalmology (Auckland, N.Z.), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Detailed Analysis of Intraretinal Layers and Their Correlation to Brain Structures in Normal Healthy Aging.Translational vision science & technology · 2026Article
- Longitudinal Analysis of Retinal Microvascular and Choroidal Imaging Parameters in Parkinson's Disease Compared with Controls.Ophthalmology science · 2023Article
- Normative Database for All Retinal Layer Thicknesses Using SD-OCT Posterior Pole Algorithm and the Effects of Age, Gender and Axial Lenght.Journal of clinical medicine · 2020Article
- Age-related changes of individual macular retinal layers among Asians.Scientific reports · 2019Article
- Determinants of Macular Layers and Optic Disc Characteristics on SD-OCT: The Rhineland Study.Translational vision science & technology · 2019Article
- Ratiometric Analysis ofTranslational biophotonicsArticle
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Authors and funding
8 authors.
Funding
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Abstract
purposeTo assess alterations of retinal layers in healthy subjects over 60 years old.
methodsRetinal layers of 160 healthy subjects (aged 60-100 years) without any retinal pathology were imaged using spectral domain optical coherence tomography. Mean thickness of retinal nerve fiber layer, ganglion cell/inner plexiform layer (GCLIPL), inner nuclear layer, outer plexiform layer/outer nuclear layer, photoreceptor complex (PR) and retinal thickness (RT) were measured in a 3.45 mm grid. Correlations between age and layers were estimated and linear regression equations were calculated. Different age-groups (60-69, 70-79, 80-89 years and nonagenarians, each group with 40 participants) were compared.
resultsSignificant age-thickness correlations were observed for GCLIPL (
conclusionOur study provides normative data of alterations of retinal layers for persons aged 60 years to nonagenarians and indicates a continuous decrease of RT, PR, and GCLIPL. This data may be useful for clinical trials investigating macular diseases in older patients.
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