ArticleScientific reports2017
An oxytocin-dependent social interaction between larvae and adult C. elegans.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 42 citations in OpenAlex.
- Assessing genetic conservation of human sociability-linked genes in C. elegans.Behavior genetics · 2025Article
- Conserved autism-associated genes tune social feeding behavior in C. elegans.Nature communications · 2024Article
- Evolutionary conserved peptide and glycoprotein hormone-like neuroendocrine systems in C. elegans.Molecular and cellular endocrinology · 2024Article
- Conserved autism-associated genes tune social feeding behavior inbioRxiv : the preprint server for biology · 2023Article
- Article
- Sex-specific, pdfr-1-dependent modulation of pheromone avoidance by food abundance enables flexibility in C. elegans foraging behavior.Current biology : CB · 2021Article
- An oxytocin/vasopressin-related neuropeptide modulates social foraging behavior in the clonal raider ant.PLoS biology · 2021Article
- Neuroligin dependence of social behaviour in Caenorhabditis elegans provides a model to investigate an autism-associated gene.Human molecular genetics · 2021Article
- Investigating autism associated genes in C. elegans reveals candidates with a role in social behaviour.PloS one · 2021Article
- Exposure to dexamethasone modifies transcriptomic responses of free-living stages of Strongyloides stercoralis.PloS one · 2021Article
- Vasopressin Promoter Transgenic and Vasopressin Gene-Edited Ascidian,Frontiers in endocrinology · 2021Article
- Report on the First Symposium on Invertebrate Neuroscience held on 13-17th August 2019 at the Balaton Limnological Institute, MTA Centre for Ecological Research, Tihany, Hungary.Invertebrate neuroscience : IN · 2020Article
- MeasuringGenetics · 2020Article
- Comparative and Evolutionary Physiology of Vasopressin/ Oxytocin-Type Neuropeptide Signaling in Invertebrates.Frontiers in endocrinology · 2020Review
- Social creatures: Model animal systems for studying the neuroendocrine mechanisms of social behaviour.Journal of neuroendocrinology · 2019Review
- A primer on pheromone signaling in Caenorhabditis elegans for systems biologists.Current opinion in systems biology · 2019Article
- Intra Strain Variation of the Effects of Gram-Negative ESKAPE Pathogens on Intestinal Colonization, Host Viability, and Host Response in the Model OrganismFrontiers in microbiology · 2019Article
- Oxytocin-like signaling in ants influences metabolic gene expression and locomotor activity.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2018Article
- Effects of Larval Density on Gene Regulation inG3 (Bethesda, Md.) · 2018Article
- Social and sexual behaviors inJournal of neurogeneticsArticle
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
Abstract
Oxytocin has a conserved role in regulating animal social behaviour including parental-offspring interactions. Recently an oxytocin-like neuropeptide, nematocin, and its cognate receptors have been identified in the nematode Caenorhabditis elegans. We provide evidence for a pheromone signal produced by C. elegans larvae that modifies the behaviour of adult animals in an oxytocin-dependent manner increasing their probability of leaving a food patch which the larvae are populating. This increase is positively correlated to the size of the larval population but cannot be explained by food depletion nor is it modulated by biogenic amines, which suggest it is not an aversive behaviour. Moreover, the food-leaving behaviour is conspecific and pheromone dependent: C. elegans adults respond more strongly to C. elegans larvae compared to other nematode species and this effect is absent in C. elegans daf-22 larvae which are pheromone deficient. Neurotransmitter receptors previously implicated in C. elegans foraging decisions NPR-1 and TYRA-3, for NPY-like neuropeptides and tyramine respectively, do not appear to be involved in oxytocin-dependent adult food-leaving. We conclude oxytocin signals within a novel neural circuit that regulates parental-offspring social behaviour in C. elegans and that this provides evidence for evolutionary conservation of molecular components of a parental decision making behaviour.
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