ArticleScientific reports2017
Odorant-odorant metabolic interaction, a novel actor in olfactory perception and behavioral responsiveness.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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11 citing papers in PubMed, 33 citations in OpenAlex.
- Odour learning concentration influences concentration range of conditioned response in newborn rabbits.Scientific reports · 2025Article
- Ex Vivo Multisite Electro-olfactogram Recordings in Rabbit Neonates.Methods in molecular biology (Clifton, N.J.) · 2025Article
- RNAseq analysis of olfactory neuroepithelium cytological samples in individuals with Down syndrome compared to euploid controls: a pilot study.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2023Article
- Role of Insect and Mammal Glutathione Transferases in Chemoperception.Biomolecules · 2023Review
- Odorant Metabolism in Humans.Angewandte Chemie (International ed. in English) · 2022Review
- The odorant metabolizing enzyme UGT2A1: Immunolocalization and impact of the modulation of its activity on the olfactory response.PloS one · 2021Article
- Odor coding in the mammalian olfactory epithelium.Cell and tissue research · 2021Review
- Feasibility of integrating canine olfaction with chemical and microbial profiling of urine to detect lethal prostate cancer.PloS one · 2021Article
- Nasal mucus glutathione transferase activity and impact on olfactory perception and neonatal behavior.Scientific reports · 2019Article
- Ex vivo real-time monitoring of volatile metabolites resulting from nasal odorant metabolism.Scientific reports · 2019Article
- The human olfactory cleft mucus proteome and its age-related changes.Scientific reports · 2018Article
Corrections and comments
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Authors and funding
7 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the nasal olfactory epithelium, olfactory metabolic enzymes ensure odorant clearance from the olfactory receptor environment. This biotransformation of odorants into deactivated polar metabolites is critical to maintaining peripheral sensitivity and perception. Olfactory stimuli consist of complex mixtures of odorants, so binding interactions likely occur at the enzyme level and may impact odor processing. Here, we used the well-described model of mammary pheromone-induced sucking-related behavior in rabbit neonates. It allowed to demonstrate how the presence of different aldehydic odorants efficiently affects the olfactory metabolism of this pheromone (an aldehyde too: 2-methylbut-2-enal). Indeed, according to in vitro and ex vivo measures, this metabolic interaction enhances the pheromone availability in the epithelium. Furthermore, in vivo presentation of the mammary pheromone at subthreshold concentrations efficiently triggers behavioral responsiveness in neonates when the pheromone is in mixture with a metabolic challenger odorant. These findings reveal that the periphery of the olfactory system is the place of metabolic interaction between odorants that may lead, in the context of odor mixture processing, to pertinent signal detection and corresponding behavioral effect.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.