ArticleScientific reports2017
Bi-directional and shared epigenomic signatures following proton and
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Meta-analysis of Cognitive Performance by Novel Object Recognition after Proton and Heavy Ion Exposures.Radiation research · 2019Pooled it
- Irradiation and Alterations in Hippocampal DNA Methylation.Epigenomes · 2024Review
- Effects of 5-ion 6-beam sequential irradiation in the presence and absence of hindlimb or control hindlimb unloading on behavioral performances and plasma metabolic pathways of Fischer 344 rats.Frontiers in physiology · 2024Article
- Review
- Postsynaptic density radiation signature following space irradiation.Frontiers in physiology · 2023Article
- Comparative Analysis of Behavioral Reactions and Morphological Changes in the Rat Brain After Exposure to Ionizing Radiation with Different Physical Characteristics.Cellular and molecular neurobiology · 2023Article
- Space Radiation-Induced Alterations in the Hippocampal Ubiquitin-Proteome System.International journal of molecular sciences · 2021Article
- Amifostine (WR-2721) Mitigates Cognitive Injury Induced by Heavy Ion Radiation in Male Mice and Alters Behavior and Brain Connectivity.Frontiers in physiology · 2021Article
- Epigenetic Regulation of the Hippocampus, with Special Reference to Radiation Exposure.International journal of molecular sciences · 2020Review
- The Impact of Environmental Factors on 5-Hydroxymethylcytosine in the Brain.Current environmental health reports · 2020Review
- Late Effects ofFrontiers in behavioral neuroscience · 2020Article
- Risks of cognitive detriments after low dose heavy ion and proton exposures.International journal of radiation biology · 2019Review
- Behavioral effects of space radiation: A comprehensive review of animal studies.Life sciences in space research · 2019Review
- Integrated Metabolomics-DNA Methylation Analysis Reveals Significant Long-Term Tissue-Dependent Directional Alterations in Aminoacyl-tRNA Biosynthesis in the Left Ventricle of the Heart and Hippocampus Following Proton Irradiation.Frontiers in molecular biosciences · 2019Article
- Combined Effects of Three High-Energy Charged Particle Beams Important for Space Flight on Brain, Behavioral and Cognitive Endpoints in B6D2F1 Female and Male Mice.Frontiers in physiology · 2019Article
- Central Nervous System Responses to Simulated Galactic Cosmic Rays.International journal of molecular sciences · 2018Review
- Female mice are protected from space radiation-induced maladaptive responses.Brain, behavior, and immunity · 2018Article
- Whole-BodyInternational journal of molecular sciences · 2018Article
- Temporary microglia-depletion after cosmic radiation modifies phagocytic activity and prevents cognitive deficits.Scientific reports · 2018Article
- Galactic Cosmic Radiation Induces Persistent Epigenome Alterations Relevant to Human Lung Cancer.Scientific reports · 2018Article
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
The brain's response to radiation exposure is an important concern for patients undergoing cancer therapy and astronauts on long missions in deep space. We assessed whether this response is specific and prolonged and is linked to epigenetic mechanisms. We focused on the response of the hippocampus at early (2-weeks) and late (20-week) time points following whole body proton irradiation. We examined two forms of DNA methylation, cytosine methylation (5mC) and hydroxymethylation (5hmC). Impairments in object recognition, spatial memory retention, and network stability following proton irradiation were observed at the two-week time point and correlated with altered gene expression and 5hmC profiles that mapped to specific gene ontology pathways. Significant overlap was observed between DNA methylation changes at the 2 and 20-week time points demonstrating specificity and retention of changes in response to radiation. Moreover, a novel class of DNA methylation change was observed following an environmental challenge (i.e. space irradiation), characterized by both increased and decreased 5hmC levels along the entire gene body. These changes were mapped to genes encoding neuronal functions including postsynaptic gene ontology categories. Thus, the brain's response to proton irradiation is both specific and prolonged and involves novel remodeling of non-random regions of the epigenome.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.