Evidence map›Paper›PMID 28860163›Full record

ArticleJournal of the American Society of Nephrology : JASN2017

Proximal Tubular Cannabinoid-1 Receptor Regulates Obesity-Induced CKD.

Shiran Udi, Liad Hinden, Brian Earley, Adi Drori, Noa Reuveni, Rivka Hadar, Resat Cinar, Alina Nemirovski, Joseph Tam

Open access · bronzeAbstract read
In one paragraph

Article in Journal of the American Society of Nephrology : JASN, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
67citing papers in PubMed, 1 pooled it
7.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

67 citing papers in PubMed, 1 synthesis or guideline pooled it, 95 citations in OpenAlex.

  1. Lipid homeostasis in diabetic kidney disease.International journal of biological sciences · 2024
    Pooled it
  2. Article
  3. N-methyl-D-aspartate receptor inhibition protects against obesity-induced kidney disease.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2026
    Article
  4. Review
  5. Article
  6. Review
  7. Genetic Tools in Rodents to Study Cannabinoid Functions.Current topics in behavioral neurosciences · 2026
    Review
  8. The effects of Cannabidiol on podocytes in vitro.Biochemical and biophysical research communications · 2025
    Article
  9. Review
  10. Article
  11. Article
  12. Review
  13. Review
  14. The effects of cannabinoids on the kidney.Acta physiologica (Oxford, England) · 2024
    Review
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article

7 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Shiran UdiObesity and Metabolism Laboratory, Institute for Drug Research, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel.
Liad HindenObesity and Metabolism Laboratory, Institute for Drug Research, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel.
Brian EarleyLaboratory of Physiological Studies, National Institute on Alcohol Abuse and Alcoholism, Bethesda, Maryland.
Adi DroriObesity and Metabolism Laboratory, Institute for Drug Research, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel.
Noa ReuveniObesity and Metabolism Laboratory, Institute for Drug Research, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel.
Rivka HadarObesity and Metabolism Laboratory, Institute for Drug Research, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel.
Resat CinarLaboratory of Physiological Studies, National Institute on Alcohol Abuse and Alcoholism, Bethesda, Maryland.
Alina NemirovskiObesity and Metabolism Laboratory, Institute for Drug Research, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel.
Joseph TamObesity and Metabolism Laboratory, Institute for Drug Research, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel; yossit@ekmd.huji.ac.il.
Hebrew University of Jerusalem · ILNational Institute on Alcohol Abuse and Alcoholism · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Obesity-related structural and functional changes in the kidney develop early in the course of obesity and occur independently of hypertension, diabetes, and dyslipidemia. Activating the renal cannabinoid-1 receptor (CB

Indexed as

Gene Expression RegulationAMP-Activated Protein KinasesAnimalsBody WeightCell LineFatty AcidsFibrosisGene DeletionGenotypeHeterozygoteHumansInflammationKidney Failure, ChronicKidney Tubules, ProximalMaleMiceAMP-Activated Protein KinasesFatty AcidsOxygenProtein Serine-Threonine KinasesReceptor, Cannabinoid, CB1Stk11 protein, mouseAMPKCB1 receptorchronic kidney diseaseEndocannabinoidsobesityRenal Proximal Tubular Cell

Identifiers

PMID28860163
PMCPMC5698062
OpenAlexW2751534001

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.