Evidence map›Paper›PMID 28860122›Full record

ArticleCirculation2017

Exercise-Induced Changes in Glucose Metabolism Promote Physiological Cardiac Growth.

Andrew A Gibb, Paul N Epstein, Shizuka Uchida, Yuting Zheng, Lindsey A McNally, Detlef Obal, Kartik Katragadda, Patrick Trainor, Daniel J Conklin, Kenneth R Brittian and 5 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Circulation, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 97 papers.

0numbers the graph read from it
0cells of the map it votes in
97citing papers in PubMed
7.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

97 citing papers in PubMed, 149 citations in OpenAlex.

  1. Article
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  7. Physical Activity and Its Impact on Cardiometabolic Disorders.Handbook of experimental pharmacology · 2026
    Review
  8. [Overwork damages myocardial energy metabolism homeostasis in mice].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2025
    Article
  9. Exercise intensity and cardiac metabolic adaptations in elderly heart failure rehabilitation: A review.International journal of cardiology. Cardiovascular risk and prevention · 2025
    Review
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37 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 3 countries.

Andrew A GibbInstitute of Molecular Cardiology (A.A.G., Y.Z., L.A.M., K.K., P.T., D.J.C., K.R.B., S.P.J., A.B., B.G.H.).
Paul N EpsteinDepartment of Pediatrics (P.N.E.).
Shizuka UchidaCardiovascular Innovation Institute (S.U.).
Yuting ZhengInstitute of Molecular Cardiology (A.A.G., Y.Z., L.A.M., K.K., P.T., D.J.C., K.R.B., S.P.J., A.B., B.G.H.).
Lindsey A McNallyInstitute of Molecular Cardiology (A.A.G., Y.Z., L.A.M., K.K., P.T., D.J.C., K.R.B., S.P.J., A.B., B.G.H.).
Detlef ObalDiabetes and Obesity Center (A.A.G., Y.Z., L.A.M., D.O., K.K., P.T., D.J.C., K.R.B., S.P.J., A.B., B.G.H.).
Kartik KatragaddaInstitute of Molecular Cardiology (A.A.G., Y.Z., L.A.M., K.K., P.T., D.J.C., K.R.B., S.P.J., A.B., B.G.H.).
Patrick TrainorInstitute of Molecular Cardiology (A.A.G., Y.Z., L.A.M., K.K., P.T., D.J.C., K.R.B., S.P.J., A.B., B.G.H.).
Daniel J ConklinInstitute of Molecular Cardiology (A.A.G., Y.Z., L.A.M., K.K., P.T., D.J.C., K.R.B., S.P.J., A.B., B.G.H.).
Kenneth R BrittianInstitute of Molecular Cardiology (A.A.G., Y.Z., L.A.M., K.K., P.T., D.J.C., K.R.B., S.P.J., A.B., B.G.H.).
Michael T TsengDepartment of Anatomy and Neuroscience (M.T.T.).
Jianxun WangUniversity of Louisville, KY. Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA (J.W.).
Steven P JonesInstitute of Molecular Cardiology (A.A.G., Y.Z., L.A.M., K.K., P.T., D.J.C., K.R.B., S.P.J., A.B., B.G.H.).
Aruni BhatnagarInstitute of Molecular Cardiology (A.A.G., Y.Z., L.A.M., K.K., P.T., D.J.C., K.R.B., S.P.J., A.B., B.G.H.).
Bradford G HillInstitute of Molecular Cardiology (A.A.G., Y.Z., L.A.M., K.K., P.T., D.J.C., K.R.B., S.P.J., A.B., B.G.H.) bradford.hill@louisville.edu.
MACOM (United States) · USDiabetes Australia · AUInstitute for Learning Innovation · USNeurosciences Institute · USPower+Energy (United States) · US

Funding

Tumor Necrosis Factor Modulation of CPCsP01HL078825 · NHLBI · UNIVERSITY OF LOUISVILLE · PI BOLLI, ROBERTO · 2005 to 2021
$37.6M
Project 5 - Metabolomic Analysis of AtherothrombosisP20GM103492 · NIGMS · UNIVERSITY OF LOUISVILLE · PI DEFILIPPIS, ANDREW · 2012 to 2017
$13.8M
TOXICITY OF 4-HYDROXYALKENALS IN HEARTR01HL055477 · NHLBI · UNIVERSITY OF TEXAS MEDICAL BR GALVESTON · PI BHATNAGAR, ARUNI · 1997 to 2015
$4.4M
Regulation of Metabolic Genes in the HeartR01HL131647 · NHLBI · UNIVERSITY OF LOUISVILLE · PI JONES, STEVEN P · 2016 to 2019
$2.2M
Metabolic optimization of cell therapyR01HL130174 · NHLBI · UNIVERSITY OF LOUISVILLE · PI HILL, BRADFORD GUY · 2016 to 2020
$1.9M
Metabolic regulation of cardiac stem cellsR56HL122580 · NHLBI · UNIVERSITY OF LOUISVILLE · PI HILL, BRADFORD GUY · 2015 to 2015
$381k
American Heart Association-American Stroke Association 16PRE31010022NHLBI NIH HHS P01 HL078825NHLBI NIH HHS R01 HL055477NHLBI NIH HHS R01 HL130174NHLBI NIH HHS R01 HL131647NHLBI NIH HHS R56 HL122580NIGMS NIH HHS P20 GM103492
6 · The paper itself

Abstract

backgroundExercise promotes metabolic remodeling in the heart, which is associated with physiological cardiac growth; however, it is not known whether or how physical activity-induced changes in cardiac metabolism cause myocardial remodeling. In this study, we tested whether exercise-mediated changes in cardiomyocyte glucose metabolism are important for physiological cardiac growth.

methodsWe used radiometric, immunologic, metabolomic, and biochemical assays to measure changes in myocardial glucose metabolism in mice subjected to acute and chronic treadmill exercise. To assess the relevance of changes in glycolytic activity, we determined how cardiac-specific expression of mutant forms of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase affect cardiac structure, function, metabolism, and gene programs relevant to cardiac remodeling. Metabolomic and transcriptomic screenings were used to identify metabolic pathways and gene sets regulated by glycolytic activity in the heart.

resultsExercise acutely decreased glucose utilization via glycolysis by modulating circulating substrates and reducing phosphofructokinase activity; however, in the recovered state following exercise adaptation, there was an increase in myocardial phosphofructokinase activity and glycolysis. In mice, cardiac-specific expression of a kinase-deficient 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase transgene (Glyco

conclusionsExercise-induced decreases in glycolytic activity stimulate physiological cardiac remodeling, and metabolic flexibility is important for maintaining mitochondrial health in the heart.

Indexed as

GlycolysisPhysical ExertionVentricular RemodelingAdaptation, PhysiologicalAnimalsCardiomegaly, Exercise-InducedExercise ToleranceFatty AcidsGene Expression ProfilingGene Expression RegulationGenotypeGlucoseHeartIsolated Heart PreparationMaleMetabolomicsFatty AcidsGlucosePhosphofructokinase-2exerciseglycolysishypertrophymetabolomicsmitochondriaventricular remodeling

Identifiers

PMID28860122
PMCPMC5704654
OpenAlexW2753846719

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.