Evidence map›Paper›PMID 28860115›Full record

ArticleDevelopment (Cambridge, England)2017

Afadin orients cell division to position the tubule lumen in developing renal tubules.

Lei Gao, Zhufeng Yang, Chitkale Hiremath, Susan E Zimmerman, Blake Long, Paul R Brakeman, Keith E Mostov, David M Bryant, Katherine Luby-Phelps, Denise K Marciano

Open access · bronzeAbstract read
In one paragraph

Article in Development (Cambridge, England), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 36 citations in OpenAlex.

  1. Article
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  7. Epithelial tubule interconnection driven by HGF-Met signaling in the kidney.Proceedings of the National Academy of Sciences of the United States of America · 2024
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  17. S6 kinase 1 at the central node of cell size and ageing.Frontiers in cell and developmental biology · 2022
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Lei GaoDepartment of Medicine, Division of Nephrology, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.
Zhufeng YangDepartment of Medicine, Division of Nephrology, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.ORCID 0000-0001-6495-2316
Chitkale HiremathDepartment of Medicine, Division of Nephrology, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.ORCID 0000-0003-1770-8112
Susan E ZimmermanDepartment of Medicine, Division of Nephrology, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.
Blake LongDepartment of Medicine, Division of Nephrology, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.
Paul R BrakemanDepartment of Pediatrics, University of California, San Francisco, CA, 94158, USA.
Keith E MostovDepartment of Anatomy, University of California, San Francisco, CA, 94158, USA.
David M BryantInstitute of Cancer Sciences, University of Glasgow and Cancer Research UK Beatson Institute, Glasgow G61 1BD, UK.
Katherine Luby-PhelpsDepartment of Cell Biology, University of Texas Southwestern Medical Center.
Denise K MarcianoDepartment of Medicine, Division of Nephrology, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA denise.marciano@utsouthwestern.edu.ORCID 0000-0003-0612-4664
The University of Texas Southwestern Medical Center · USUniversity of California, San Francisco · USCancer Research UK Scotland Institute · GB

Funding

UT Southwestern O'Brien Kidney Research Core CenterP30DK079328 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI MOE, ORSON W · 2007 to 2021
$16.9M
Recovery from acute kidney injuryR01DK074398 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MOSTOV, KEITH E · 2007 to 2015
$3.0M
Role of afadin signaling in nephron tubulogenesisR01DK099478 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI MARCIANO, DENISE K · 2014 to 2018
$1.7M
Control of Epithelial PolarityR01DK091530 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MOSTOV, KEITH E · 2011 to 2015
$1.7M
NIDDK NIH HHS P30 DK079328NIDDK NIH HHS R01 DK074398NIDDK NIH HHS R01 DK091530NIDDK NIH HHS R01 DK099478
6 · The paper itself

Abstract

In many types of tubules, continuity of the lumen is paramount to tubular function, yet how tubules generate lumen continuity

Indexed as

Cell DivisionAnimalsCells, CulturedDogsEpithelial CellsFemaleKidney Diseases, CysticKidney TubulesMadin Darby Canine Kidney CellsMaleMiceMicrofilament ProteinsMorphogenesisNephronsSpindle ApparatusafadinMicrofilament ProteinsAfadinKidney developmentLumenMouseNephronPolarityTubulogenesis

Identifiers

PMID28860115
PMCPMC5665479
OpenAlexW2752373079

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.