Evidence map›Paper›PMID 28859664›Full record

Trial reportTrials2017

Synergistic effects of aerobic exercise and cognitive training on cognition, physiological markers, daily function, and quality of life in stroke survivors with cognitive decline: study protocol for a randomized controlled trial.

Ting-Ting Yeh, Ching-Yi Wu, Yu-Wei Hsieh, Ku-Chou Chang, Lin-Chien Lee, Jen-Wen Hung, Keh-Chung Lin, Ching-Hung Teng, Yi-Han Liao

Registry-linked trialOpen access · goldAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Trials, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02550990 (Synergistic Effects of Aerobic Exercise and Cognitive Training on Cognition, Physiological Markers, Daily Function and Quality of Life in Stroke Patients With Cognitive Decline), which is not on this map. Cited by 8 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 2 pooled it
1.1field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02550990 naunknown statusnot on this map

Synergistic Effects of Aerobic Exercise and Cognitive Training on Cognition, Physiological Markers, Daily Function and Quality of Life in Stroke Patients With Cognitive Decline

TypeinterventionalSponsorChang Gung Memorial HospitalRan2015Enrolled75ConditionsStroke Patients With Cognitive DeclineArmsCognitive training, Aerobic exercise training, Sequential combination of aerobic exercise and cognitive training
3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 2 syntheses or guidelines pooled it, 27 citations in OpenAlex.

  1. Occupational therapy for cognitive impairment in stroke patients.The Cochrane database of systematic reviews · 2022
    Pooled it
  2. Physical fitness training for stroke patients.The Cochrane database of systematic reviews · 2020
    Pooled it
  3. Review
  4. Review
  5. Article
  6. Article
  7. Exercise as a prescription for patients with various diseases.Journal of sport and health science · 2019
    Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 1 country.

Ting-Ting YehSchool of Occupational Therapy, College of Medicine, National Taiwan University, Taipei, Taiwan.
Ching-Yi WuDepartment of Occupational Therapy and Graduate Institute of Behavioral Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan. cywu@mail.cgu.edu.tw.ORCID 0000-0003-4726-2916
Yu-Wei HsiehDepartment of Occupational Therapy and Graduate Institute of Behavioral Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan.
Ku-Chou ChangDepartment of Neurology, Chang Gung Memorial Hospital, Kaohsiung, Taiwan. kcchang@cgmh.org.tw.
Lin-Chien LeeDepartment of Physical Medicine and Rehabilitation, Cheng Hsin General Hospital, Taipei, Taiwan.
Jen-Wen HungDepartment of Rehabilitation, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University, College of Medicine, Kaohsiung, Taiwan.
Keh-Chung LinSchool of Occupational Therapy, College of Medicine, National Taiwan University, Taipei, Taiwan.
Ching-Hung TengDepartment of Occupational Therapy and Graduate Institute of Behavioral Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan.
Yi-Han LiaoDepartment of Occupational Therapy and Graduate Institute of Behavioral Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan.
Chang Gung University · TWNational Taiwan University · TWChang Gung University of Science and Technology · TWCheng Hsin General Hospital · TWKaohsiung Chang Gung Memorial Hospital · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAerobic exercise and cognitive training have been effective in improving cognitive functions; however, whether the combination of these two can further enhance cognition and clinical outcomes in stroke survivors with cognitive decline remains unknown. This study aimed to determine the treatment effects of a sequential combination of aerobic exercise and cognitive training on cognitive function and clinical outcomes. METHODS/

designStroke survivors (n = 75) with cognitive decline will be recruited and randomly assigned to cognitive training, aerobic exercise, and sequential combination of aerobic exercise and cognitive training groups. All participants will receive training for 60 minutes per day, 3 days per week for 12 weeks. The aerobic exercise group will receive stationary bicycle training, the cognitive training group will receive cognitive-based training, and the sequential group will first receive 30 minutes of aerobic exercise, followed by 30 minutes of cognitive training. The outcome measures involve cognitive functions, physiological biomarkers, daily function and quality of life, physical functions, and social participation. Participants will be assessed before and immediately after the interventions, and 6 months after the interventions. Repeated measures of analysis of variance will be used to evaluate the changes in outcome measures at the three assessments. DISCUSSION: This trial aims to explore the benefits of innovative intervention approaches to improve the cognitive function, physiological markers, daily function, and quality of life in stroke survivors with cognitive decline. The findings will provide evidence to advance post-stroke cognitive rehabilitation.

trial registrationClinicalTrials.gov, NCT02550990 . Registered on 6 September 2015.

Indexed as

CognitionCognitive Behavioral TherapyActivities of Daily LivingAdultAgedAged, 80 and overBicyclingClinical ProtocolsCognition DisordersCombined Modality TherapyDisability EvaluationExercise TherapyFemaleHumansMaleMental Status and Dementia TestsAerobic exerciseCognitive rehabilitationCognitive trainingSequential trainingStroke

Identifiers

PMID28859664
PMCPMC5579904
OpenAlexW2752585212

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.