Evidence map›Paper›PMID 28859530›Full record

ReviewStress (Amsterdam, Netherlands)2017

Hypothalamic-pituitary-adrenal and hypothalamic-pituitary-gonadal axes: sex differences in regulation of stress responsivity.

Mario G Oyola, Robert J Handa

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Stress (Amsterdam, Netherlands), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 349 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
349citing papers in PubMed, 5 pooled it
13.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

349 citing papers in PubMed, 5 syntheses or guidelines pooled it, 670 citations in OpenAlex.

  1. Pooled it
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  8. Multilevel sex-influenced neurobiological signatures of early life adversity.Proceedings of the National Academy of Sciences of the United States of America · 2026
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289 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Mario G Oyolaa Department of Biomedical Sciences , Colorado State University , Fort Collins , CO , USA.
Robert J Handaa Department of Biomedical Sciences , Colorado State University , Fort Collins , CO , USA.
Colorado State University · US

Funding

Estrogen Regulation of the Hypothalamo-Pituitary-Adrenal AxisR01DK105826 · NIDDK · COLORADO STATE UNIVERSITY · PI MYERS, BRENT PHILIP · 2015 to 2020
$2.1M
NIDDK NIH HHS R01 DK105826
6 · The paper itself

Abstract

Gonadal hormones play a key role in the establishment, activation, and regulation of the hypothalamic-pituitary-adrenal (HPA) axis. By influencing the response and sensitivity to releasing factors, neurotransmitters, and hormones, gonadal steroids help orchestrate the gain of the HPA axis to fine-tune the levels of stress hormones in the general circulation. From early life to adulthood, gonadal steroids can differentially affect the HPA axis, resulting in sex differences in the responsivity of this axis. The HPA axis influences many physiological functions making an organism's response to changes in the environment appropriate for its reproductive status. Although the acute HPA response to stressors is a beneficial response, constant activation of this circuitry by chronic or traumatic stressful episodes may lead to a dysregulation of the HPA axis and cause pathology. Compared to males, female mice and rats show a more robust HPA axis response, as a result of circulating estradiol levels which elevate stress hormone levels during non-threatening situations, and during and after stressors. Fluctuating levels of gonadal steroids in females across the estrous cycle are a major factor contributing to sex differences in the robustness of HPA activity in females compared to males. Moreover, gonadal steroids may also contribute to epigenetic and organizational influences on the HPA axis even before puberty. Correspondingly, crosstalk between the hypothalamic-pituitary-gonadal (HPG) and HPA axes could lead to abnormalities of stress responses. In humans, a dysregulated stress response is one of the most common symptoms seen across many neuropsychiatric disorders, and as a result, such interactions may exacerbate peripheral pathologies. In this review, we discuss the HPA and HPG axes and review how gonadal steroids interact with the HPA axis to regulate the stress circuitry during all stages in life.

Indexed as

AnimalsEstrous CycleFemaleGonadal Steroid HormonesGonadsHumansHypothalamo-Hypophyseal SystemMaleMicePituitary-Adrenal SystemRatsSex CharacteristicsSex FactorsStress, PsychologicalGonadal Steroid Hormonesestrogengonadal steroidsHypothalamic–pituitary–adrenal axishypothalamic–pituitary–gonadal axisprogesteronesex differencesstress circuitrytestosterone

Identifiers

PMID28859530
PMCPMC5815295
OpenAlexW2751431338

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.