ArticleJournal of experimental botany2017
Vitamin B1 diversity and characterization of biosynthesis genes in cassava.
Article in Journal of experimental botany, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 35 citations in OpenAlex.
- THI1 Gene Evolutionary Trends: A Comprehensive Plant-Focused Assessment via Data Mining and Large-Scale Analysis.Genome biology and evolution · 2024Article
- OsTH1 is a key player in thiamin biosynthesis in rice.Scientific reports · 2024Article
- Endophytic Bacteria Induce Thiamine (Vitamin B1) Production in Oil Palm (Tropical life sciences research · 2024Article
- A protocol for a turbidimetric assay using a Saccharomyces cerevisiae thiamin biosynthesis mutant to estimate total vitamin BPlant methods · 2023Article
- Neuroprotective effects of vitamin B1 on memory impairment and suppression of pro-inflammatory cytokines in traumatic brain injury.Metabolic brain disease · 2023Article
- Functional and comparative analysis ofPeerJ · 2023Article
- Machine learning extracts marks of thiamine's role in cold acclimation in the transcriptome ofFrontiers in plant science · 2023Article
- B vitamin supply in plants and humans: the importance of vitamer homeostasis.The Plant journal : for cell and molecular biology · 2022Review
- A novel panel of yeast assays for the assessment of thiamin and its biosynthetic intermediates in plant tissues.The New phytologist · 2022Article
- Article
- Natural Variation in Vitamin BFrontiers in plant science · 2022Article
- Variation of vitamin B contents in maize inbred lines: Potential genetic resources for biofortification.Frontiers in nutrition · 2022Article
- Metabolomic and transcriptomic profiling reveals distinct nutritional properties of cassavas with different flesh colors.Food chemistry. Molecular sciences · 2021Article
- The importance of thiamine (vitamin BThe Journal of biological chemistry · 2020Review
- Identification and characterisation of thiamine pyrophosphate (TPP) riboswitch in Elaeis guineensis.PloS one · 2020Article
- Toward Eradication of B-Vitamin Deficiencies: Considerations for Crop Biofortification.Frontiers in plant science · 2018Review
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Vitamin B1, which consists of the vitamers thiamin and its phosphorylated derivatives, is an essential micronutrient for all living organisms because it is required as a metabolic cofactor in several enzymatic reactions. Genetic diversity of vitamin B1 biosynthesis and accumulation has not been investigated in major crop species other than rice and potato. We analyzed cassava germplasm for accumulation of B1 vitamers. Vitamin B1 content in leaves and roots of 41 cassava accessions showed significant variation between accessions. HPLC analyses of B1 vitamers revealed distinct profiles in cassava leaves and storage roots, with nearly equal relative levels of thiamin pyrophosphate and thiamin monophosphate in leaves, but mostly thiamin pyrophosphate in storage roots. Unusually, the cassava genome has two genes encoding the 4-amino-2-methyl-5-hydroxymethylpyrimidine phosphate synthase, THIC (MeTHIC1 and MeTHIC2), both of which carry a riboswitch in the 3'-UTR, as well as the adenylated thiazole synthase, THI1 (MeTHI1a and MeTHI1b). The THIC and THI1 genes are expressed at very low levels in storage roots compared with the accumulation of vitamin B1, indicating only limited biosynthesis de novo therein. In leaves, vitamin B1 content is negatively correlated with THIC and THI1 expression levels, suggesting post-transcriptional regulation of THIC by the riboswitch present in the 3'-UTR of the THIC mRNA and regulation of THI1 by promoter activity or alternative post-transcriptional mechanisms.
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