ArticleInternational journal for numerical methods in biomedical engineering2018
Flow features and device-induced blood trauma in CF-VADs under a pulsatile blood flow condition: A CFD comparative study.
Article in International journal for numerical methods in biomedical engineering, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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22 citing papers in PubMed, 77 citations in OpenAlex.
- Hematologic complications and design challenges in cardiovascular devices.Communications engineering · 2026Review
- Red blood cell deformation in a microfluidic sudden expansion at supraphysiological strain rates.Biophysical journal · 2026Article
- From Early Models to Emerging Trends: The Evolution of Computational Hemolysis Prediction.Annals of biomedical engineering · 2026Review
- Numerical Analyses of Blood Pumps Under Realistic Operating Conditions.ASAIO journal (American Society for Artificial Internal Organs : 1992) · 2026Article
- Understanding the role of vascular stretch on modulation of VWF and ANGPT-2 in continuous flow left ventricular assist device (CF-VAD) patients.Lab on a chip · 2025Article
- In vitro study on device-induced damage to blood cellular components and degradation of von Willebrand factor in a CentriMag pump-assisted circulation.Artificial organs · 2024Article
- Computational fluid dynamics-based design and in vitro characterization of a novel pediatric pump-lung.Artificial organs · 2024Article
- Loss of pulsatility with continuous-flow left ventricular assist devices and the significance of the arterial endothelium in von-Willebrand factor production and degradation.Artificial organs · 2023Review
- A novel model for hemolysis estimation in rotating impeller blood pumps considering red blood cell aging.Frontiers in physiology · 2023Article
- The Impact of a New Arterial Intravascular Pump on Aorta Hemodynamic Surrounding: A Numerical Study.Bioengineering (Basel, Switzerland) · 2022Article
- A New Mathematical Numerical Model to Evaluate the Risk of Thrombosis in Three Clinical Ventricular Assist Devices.Bioengineering (Basel, Switzerland) · 2022Article
- Shear-Mediated Platelet Activation is Accompanied by Unique Alterations in Platelet Release of Lipids.Cellular and molecular bioengineering · 2021Article
- Neutrophil injury and function alterations induced by high mechanical shear stress with short exposure time.Artificial organs · 2021Article
- Model-Based Design and Optimization of Blood Oxygenators.Journal of medical devices · 2020Article
- Computational characterization of flow and blood damage potential of the new maglev CH-VAD pump versus the HVAD and HeartMate II pumps.The International journal of artificial organs · 2020Article
- Prediction of mechanical hemolysis in medical devices via a Lagrangian strain-based multiscale model.Artificial organs · 2020Article
- The impact of shear stress on device-induced platelet hemostatic dysfunction relevant to thrombosis and bleeding in mechanically assisted circulation.Artificial organs · 2020Article
- Proposal of hemodynamically improved design of an axial flow blood pump for LVAD.Medical & biological engineering & computing · 2020Article
- The role of PI3K/Akt signaling pathway in non-physiological shear stress-induced platelet activation.Artificial organs · 2019Article
- Device-induced platelet dysfunction in mechanically assisted circulation increases the risks of thrombosis and bleeding.Artificial organs · 2019Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
In this study, the flow features and device-associated blood trauma in 4 clinical ventricular assist devices (VADs; 2 implantable axial VADs, 1 implantable centrifugal VAD, and 1 extracorporeal VAD) were computationally analyzed under clinically relevant pulsatile flow conditions. The 4 VADs were operated at fixed pump speed at a mean rate of 4.5 L/min. Mean pressure difference, wall shear stress, volume distribution of scalar shear stress (SSS), and shear-induced hemolysis index (HI) were derived from the flow field of each VAD and were compared. The computationally predicted mean pressure difference across the 3 implantable VADs was ~70 mmHg, and the extracorporeal VAD was ~345 mmHg, which matched well with their reported pressure-flow curves. The axial VADs had higher mean wall shear stress and SSS compared with the centrifugal VADs. However, the residence time of the centrifugal VADs was much longer compared with the axial VADs because of the large volume of the centrifugal VADs. The highest SSS was observed in one axial VAD, and the longest exposure time was observed in 1 centrifugal VAD. These 2 VADs generated the highest HI. The shear-induced HI varied as a function of flow rate within each cardiac cycle. At fixed pump speed, the HI was greatest at low flow rate due to longer exposure time to shear stress compared with at high flow rate. Subsequently, we hypothesize that to reduce the risk of blood trauma during VAD support, shear stress magnitude and exposure time need to be minimized.
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