Evidence map›Paper›PMID 28859104›Full record

ArticlePloS one2017

Near-infrared fluorescence imaging and photodynamic therapy with indocyanine green lactosome has antineoplastic effects for hepatocellular carcinoma.

Takumi Tsuda, Masaki Kaibori, Hidehiko Hishikawa, Richi Nakatake, Tadayoshi Okumura, Eiichi Ozeki, Isao Hara, Yuji Morimoto, Kengo Yoshii, Masanori Kon

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 35 citations in OpenAlex.

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  18. Innovative treatment for hepatocellular carcinoma (HCC).Translational gastroenterology and hepatology · 2018
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Takumi TsudaDepartment of Surgery, Kansai Medical University, Hirakata, Osaka, Japan.
Masaki KaiboriDepartment of Surgery, Kansai Medical University, Hirakata, Osaka, Japan.
Hidehiko HishikawaDepartment of Surgery, Kansai Medical University, Hirakata, Osaka, Japan.
Richi NakatakeDepartment of Surgery, Kansai Medical University, Hirakata, Osaka, Japan.
Tadayoshi OkumuraDepartment of Surgery, Kansai Medical University, Hirakata, Osaka, Japan.
Eiichi OzekiTechnology Research Laboratory, Shimadzu Corporation, Kyoto, Japan.
Isao HaraTechnology Research Laboratory, Shimadzu Corporation, Kyoto, Japan.
Yuji MorimotoDepartment of Integrative Physiology and Bio-Nano Medicine, National Defense Medical College, Tokorozawa, Saitama, Japan.
Kengo YoshiiDepartment of Mathematics and Statistics in Medical Sciences, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Masanori KonDepartment of Surgery, Kansai Medical University, Hirakata, Osaka, Japan.
Kansai Medical University · JPShimadzu (Japan) · JPKyoto Prefectural University of Medicine · JPNational Defense Medical College · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAnticancer agents and operating procedures have been developed for hepatocellular carcinoma (HCC) patients, but their prognosis remains poor. It is necessary to develop novel diagnostic and therapeutic strategies for HCC to improve its prognosis. Lactosome is a core-shell-type polymeric micelle, and enclosing labeling or anticancer agents into this micelle enables drug delivery. In this study, we investigated the diagnostic and therapeutic efficacies of indocyanine green (ICG)-loaded lactosome for near-infrared fluorescence (NIF) imaging and photodynamic therapy (PDT) for HCC.

methodsThe human HCC cell line HuH-7 was treated with ICG or ICG-lactosome, followed by PDT, and the cell viabilities were measured (in vitro PDT efficiency). For NIF imaging, HuH-7 cells were subcutaneously transplanted into BALB/c nude mice, followed by intravenous administration of ICG or ICG-lactosome. The transplanted animals were treated with PDT, and the antineoplastic effects were analyzed (in vivo PDT efficiency).

resultsPDT had toxic effects on HuH-7 cells treated with ICG-lactosome, but not ICG alone. NIF imaging revealed that the fluorescence of tumor areas in ICG-lactosome-treated animals was higher than that of contralateral regions at 24 h after injection and thereafter. PDT exerted immediate and continuous phototoxic effects in the transplanted mice treated with ICG-lactosome.

conclusionsOur results demonstrate that ICG-lactosome accumulated in xenograft tumors, and that PDT had antineoplastic effects on these malignant implants. NIF imaging and PDT with ICG-lactosome could be useful diagnostic and/or therapeutic strategies for HCC.

Indexed as

PhotochemotherapyAnimalsCarcinoma, HepatocellularCell Line, TumorCell SurvivalHumansIndocyanine GreenLiver NeoplasmsMiceOptical ImagingXenograft Model Antitumor AssaysIndocyanine Green

Identifiers

PMID28859104
PMCPMC5578495
OpenAlexW2753077577

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.