ArticlePloS one2017
Exacerbation of colon carcinogenesis by Blastocystis sp.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.
- Global prevalence and correlation of intestinal parasitic infections in patients with colorectal cancer: a systematic review and meta-analysis.BMC gastroenterology · 2025Pooled it
- Blastocystis, an Enigmatic Parasite.Acta parasitologica · 2026Review
- Differential Metabolic and Transcriptional Responses of PBMCs to Blastocystis sp. Subtypes in Chemotherapy-Treated Colorectal Cancer Patients.Acta parasitologica · 2026Article
- Prevalence of Blastocystis infection in patients with colorectal cancer in Taiwan.BMC infectious diseases · 2025Article
- The Role ofPathogens (Basel, Switzerland) · 2025Review
- Prevalence and molecular identification of protozoan intestinal parasitic infections in cancer patients and a control group.BMC infectious diseases · 2024Article
- An Update onMicroorganisms · 2024Review
- Effect ofJournal of parasitic diseases : official organ of the Indian Society for Parasitology · 2024Article
- Systematic Review and Meta-Analysis: Epidemiology of HumanTropical medicine and infectious disease · 2023Review
- Levels of Genetic Variants Among Symptomatic Blastocystis Subtypes and their Relationship to Mucosal Immune Surveillance in the Precancerous Colons of Experimentally Infected Rats.Acta parasitologica · 2023Article
- The associated risk ofFrontiers in oncology · 2023Article
- Are Blastocystis hominis and Cryptosporidium spp. playing a positive role in colorectal cancer risk? A systematic review and meta-analysis.Infectious agents and cancer · 2022Review
- An Association Between Blastocystis Subtypes and Colorectal Cancer Patients: A Significant Different Profile from Non-cancer Individuals.Acta parasitologica · 2022Article
- Protozoan Intestinal Parasitic Infection in Patients with Hematological Malignancies.Journal of clinical medicine · 2022Article
- Association ofWorld journal of gastrointestinal oncology · 2022Article
- Influence ofJournal of parasitic diseases : official organ of the Indian Society for Parasitology · 2022Article
- Prevalence ofAnimals : an open access journal from MDPI · 2022Article
- The synthesis of extracellular vesicles by the protistan parasiteFrontiers in cellular and infection microbiology · 2022Article
- Exosomes secreted byFrontiers in medicine · 2022Article
- Molecular Characterization ofAnimals : an open access journal from MDPI · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Colorectal cancer (CRC) is one the most commonly diagnosed cancers worldwide and the number is increasing every year. Despite advances in screening programs, CRC remains as the second leading cause of cancer deaths in the United States. Oxidative stress plays an important role in the molecular mechanisms of colorectal cancer (CRC) and has been shown to be associated with Blastocystis sp., a common intestinal microorganism. In the present study, we aimed to identify a role for Blastocystis sp. in exacerbating carcinogenesis using in vivo rat model. Methylene blue staining was used to identify colonic aberrant crypt foci (ACF) and adenomas formation in infected rats whilst elevation of oxidative stress biomarker levels in the urine and serum samples were evaluated using biochemical assays. Histological changes of the intestinal mucosa were observed and a significant number of ACF was found in Blastocystis sp. infected AOM-rats compared to the AOM-controls. High levels of urinary oxidative indices including advanced oxidative protein products (AOPP) and hydrogen peroxide were observed in Blastocystis sp. infected AOM-rats compared to the uninfected AOM-rats. Our study provides evidence that Blastocystis sp. has a significant role in enhancing AOM-induced carcinogenesis by resulting damage to the intestinal epithelium and promoting oxidative damage in Blastocystis sp. infected rats.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.