ArticleEnvironmental research2017
Sex differences in sensitivity to prenatal and early childhood manganese exposure on neuromotor function in adolescents.
Article in Environmental research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.
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Who cites it
37 citing papers in PubMed, 1 synthesis or guideline pooled it, 71 citations in OpenAlex.
- Biomarkers of environmental manganese exposure and associations with childhood neurodevelopment: a systematic review and meta-analysis.Environmental health : a global access science source · 2020Pooled it
- Body composition and neuromotor development in the year after NICU discharge in premature infants.Pediatric research · 2020Trial
- Sexual dimorphism in the programming effects of prenatal manganese multi-media biomarker on temporal cognition in school-aged children.Scientific reports · 2026Article
- Prenatal exposure to manganese and objectively measured sleep disturbances in early childhood.Environmental research · 2025Article
- Dentin Metal and Trace Elements in Deciduous Teeth: Findings from Project Viva.Environmental science & technology · 2025Article
- Article
- Deciduous teeth from the New Hampshire birth cohort study: Early life environmental and dietary predictors of dentin elements.Environmental research · 2024Article
- Sex-specific associations of a ferroalloy metal mixture with motor function in Italian adolescents.Environmental epidemiology (Philadelphia, Pa.) · 2024Article
- Child and Adolescent Manganese Biomarkers and Adolescent Postural Balance in Marietta CARES Cohort Participants.Environmental health perspectives · 2024Article
- An Industry-Relevant Metal Mixture, Iron Status, and Reported Attention-Related Behaviors in Italian Adolescents.Environmental health perspectives · 2024Article
- Early life manganese exposure and reported attention-related behaviors in Italian adolescents.Environmental epidemiology (Philadelphia, Pa.) · 2023Article
- Prenatal manganese biomarkers and operant test battery performance in Mexican children: Effect modification by child sex.Environmental research · 2023Article
- Sex-specific association between prenatal manganese exposure and working memory in school-aged children in Mexico city: An exploratory multi-media approach.Environmental pollution (Barking, Essex : 1987) · 2023Article
- Early-Life Critical Windows of Susceptibility to Manganese Exposure and Sex-Specific Changes in Brain Connectivity in Late Adolescence.Biological psychiatry global open science · 2023Article
- Impact of COVID-19-Related Social Isolation on Behavioral Outcomes in Young Adults Residing in Northern Italy.International journal of environmental research and public health · 2022Article
- Validation of blood arsenic and manganese assessment from archived clotted erythrocyte fraction in an urban cohort of mother-child dyads.The Science of the total environment · 2022Article
- Prenatal metal mixture concentrations and reward motivation in children.Neurotoxicology · 2022Article
- Role of excretion in manganese homeostasis and neurotoxicity: a historical perspective.American journal of physiology. Gastrointestinal and liver physiology · 2022Review
- Critical windows of susceptibility in the association between manganese and neurocognition in Italian adolescents living near ferro-manganese industry.Neurotoxicology · 2021Article
- Prenatal metal exposure, cord blood DNA methylation and persistence in childhood: an epigenome-wide association study of 12 metals.Clinical epigenetics · 2021Article
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Authors and funding
13 authors at 6 institutions in 2 countries.
Funding
Abstract
introductionWhile studies have suggested that exposure to manganese (Mn) may be associated with neurodevelopment in school-age children, there is limited information on prenatal and postnatal Mn exposures and tremor or motor function in children.
methodsWe measured Mn levels in dentine of shed teeth, representing prenatal, early postnatal, and cumulative childhood exposure windows, from 195 children (predominantly right-handed, 92%) in Italy. Pursuit Aiming, Luria Nebraska Motor Battery, as well as Tremor and Sway system from Computerized Adaptive Testing System (CATSYS) were administered at 11-14 years old. We examined the relationships of tooth Mn (ln-transformed) with motor function using multivariable linear regressions and generalized additive models, adjusting for age, sex, and socioeconomic status index. Effect modification by sex was also examined.
resultsWe found that higher prenatal Mn was associated with better body stability in boys in a number of sway tests (including mean sway, transversal sway, sagittal sway, sway area, and sway intensity), while Mn was associated with poorer performance in girls on all of these metrics (all p for Mn × sex interaction < 0.05). Higher prenatal Mn was also modestly associated with better hand/finger and eye-hand coordination in boys compared to girls in sex-stratified analyses, although interaction models did not reach statistical significance. For tremor, on the other hand, higher early postnatal Mn was associated with increased right-hand center frequency in girls (p for interaction < 0.01), but increased Mn level at the later postnatal period was associated with increased center frequency in boys (p for interaction = 0.01).
conclusionsThis study, which used a direct measure of prenatal and childhood Mn exposure, suggested sex-specific critical windows of early life Mn exposure in relation to neuromotor function in adolescents. The sex-specific associations might be strongest with measures of whole body stability, for which the critical exposure window was during the prenatal period.
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