ArticleNeuron2017
Specialized Representations of Value in the Orbital and Ventrolateral Prefrontal Cortex: Desirability versus Availability of Outcomes.
Article in Neuron, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 126 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
126 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Obesity is associated with reduced orbitofrontal cortex volume: A coordinate-based meta-analysis.NeuroImage. Clinical · 2020Pooled it
- μ Opioid Antagonist Naltrexone Partially Abolishes the Antidepressant Placebo Effect and Reduces Orbitofrontal Cortex Encoding of Reinforcement.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2021Trial
- A prefrontal cortex-hypothalamus circuit for heart rate control in non-human primates.bioRxiv : the preprint server for biology · 2026Article
- People, places, and things: The impact of scene animacy on emotional modulation of the early posterior negativity.Cognitive, affective & behavioral neuroscience · 2026Article
- Reversed functional gradient in primate prefrontal cortex: Posterior dominance and frontopolar task-related deactivation.Science advances · 2026Article
- Differential brain response to a highly palatable drink in chronic low back pain patients.Journal of neurophysiology · 2026Article
- Ventrolateral prefrontal cortex in macaques guides decisions in different learning conditions.Nature communications · 2026Article
- Orbitofrontal-sensory cortical interactions in learning and adaptive decision-making.Trends in cognitive sciences · 2026Review
- Prefrontal modulation of striatal engagement: a hierarchical framework for goal-directed behavior.Communications biology · 2026Review
- Dataset of cortical and subcortical single neuron activity during value-based tasks in macaque monkey.Scientific data · 2026Article
- Article
- Interaction and functional specialization across a distributed neural circuit for flexible task control in macaques.Nature communications · 2026Article
- Prefrontal cortex temporally multiplexes slow and fast dynamics in value learning and memory.Nature communications · 2025Article
- A neural circuit framework for economic choice: from building blocks of valuation to compositionality in multitasking.bioRxiv : the preprint server for biology · 2025Article
- Distinct contributions of anterior and posterior orbitofrontal cortex to outcome-guided behavior.bioRxiv : the preprint server for biology · 2025Article
- Neural coding of choice and outcome are modulated by uncertainty in orbitofrontal but not secondary motor cortex.Nature communications · 2025Article
- The Orbitofrontal Cortex Underlies Consolidation of Pavlovian Anticipatory Arousal Responses in Macaque Monkeys.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Chemogenetic inhibition of amygdala to ventrolateral prefrontal cortex communication selectively impacts contingent learning.bioRxiv : the preprint server for biology · 2025Article
- Adaptive Reinforcement Learning is causally supported by Anterior Cingulate Cortex and Striatum.bioRxiv : the preprint server for biology · 2025Article
- Stress and Inflammation Target Dorsolateral Prefrontal Cortex Function: Neural Mechanisms Underlying Weakened Cognitive Control.Biological psychiatry · 2025Review
66 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Advantageous foraging choices benefit from an estimation of two aspects of a resource's value: its current desirability and availability. Both orbitofrontal and ventrolateral prefrontal areas contribute to updating these valuations, but their precise roles remain unclear. To explore their specializations, we trained macaque monkeys on two tasks: one required updating representations of a predicted outcome's desirability, as adjusted by selective satiation, and the other required updating representations of an outcome's availability, as indexed by its probability. We evaluated performance on both tasks in three groups of monkeys: unoperated controls and those with selective, fiber-sparing lesions of either the OFC or VLPFC. Representations that depend on the VLPFC but not the OFC play a necessary role in choices based on outcome availability; in contrast, representations that depend on the OFC but not the VLPFC play a necessary role in choices based on outcome desirability.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.