Evidence map›Paper›PMID 28858616›Full record

ArticleNeuron2017

Inferior Olivary TMEM16B Mediates Cerebellar Motor Learning.

Yang Zhang, Zhushan Zhang, Shaohua Xiao, Jason Tien, Son Le, Trieu Le, Lily Y Jan, Huanghe Yang

Open access · bronzeAbstract read
In one paragraph

Article in Neuron, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 56 citations in OpenAlex.

  1. Anoctamin 2 deletion alters dopamine-related signaling and impairs inhibitory behavioral control in mice.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Article
  2. Article
  3. [Transmembrane protein 16A--a new target for the treatment of airway inflammatory diseases].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2025
    Review
  4. Amplification of Olfactory Transduction Currents Implements Sparse Stimulus Encoding.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  5. Article
  6. Review
  7. Article
  8. The CaThe Journal of physiology · 2024
    Article
  9. TMEM16 proteins: CaInternational journal of molecular medicine · 2024
    Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Polymodal Control of TMEM16x Channels and Scramblases.International journal of molecular sciences · 2022
    Review
  16. Article
  17. Article
  18. The CaActa pharmaceutica Sinica. B · 2021
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Yang ZhangDepartment of Biochemistry, Duke University Medical Center, Durham, NC 27710, USA.
Zhushan ZhangDepartment of Biochemistry, Duke University Medical Center, Durham, NC 27710, USA.
Shaohua XiaoDepartments of Physiology, Biochemistry and Biophysics, Howard Hughes Medical Institute, University of California, San Francisco, San Francisco, CA 94158, USA.
Jason TienDepartments of Physiology, Biochemistry and Biophysics, Howard Hughes Medical Institute, University of California, San Francisco, San Francisco, CA 94158, USA.
Son LeDepartment of Biochemistry, Duke University Medical Center, Durham, NC 27710, USA.
Trieu LeDepartment of Biochemistry, Duke University Medical Center, Durham, NC 27710, USA.
Lily Y JanDepartments of Physiology, Biochemistry and Biophysics, Howard Hughes Medical Institute, University of California, San Francisco, San Francisco, CA 94158, USA. Electronic address: lily.jan@ucsf.edu.
Huanghe YangDepartment of Biochemistry, Duke University Medical Center, Durham, NC 27710, USA; Department of Neurobiology, Duke University Medical Center, Durham, NC 27710, USA. Electronic address: huanghe.yang@duke.edu.
Duke Medical Center · USDuke University Hospital · USHoward Hughes Medical Institute · USUniversity of California, San Francisco · US

Funding

Molecular, Genetic & Physiological Studies of Calcium-activated Chloride ChannelsR01NS069229 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI JAN, LILY Y · 2011 to 2020
$3.5M
Ca2+ activated TMEM16 channels and their physiological roles in the brainR00NS086916 · NINDS · DUKE UNIVERSITY · PI YANG, HUANGHE · 2015 to 2017
$727k
Howard Hughes Medical InstituteNINDS NIH HHS R00 NS086916NINDS NIH HHS R01 NS069229
6 · The paper itself

Abstract

Ca

Indexed as

Action PotentialsAnimalsAnoctaminsCalciumCerebellumChloride ChannelsLearningLearning DisabilitiesMiceMice, KnockoutMotor SkillsNeuronsOlivary NucleusPurkinje CellsANO2 protein, mouseAnoctaminsCalciumChloride ChannelsANO2anoctamin-2CaCCcalcium-activated chloride channelcalcium-activated ion channelseyeblink conditioninginferior olivemotor learningolivo-cerebellumTMEM16B

Identifiers

PMID28858616
PMCPMC5659299
OpenAlexW2750986713

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.