Trial reportAnesthesia progress
Liposomal Bupivacaine Use in Third Molar Impaction Surgery: INNOVATE Study.
Trial report in Anesthesia progress. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05374499 (Double-Blinded Randomized Controlled Study Investigating the Efficacy of Exparel), which is not on this map. Cited by 11 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Double-Blinded Randomized Controlled Study Investigating the Efficacy of Exparel (Liposomal Bupivacaine) for Postoperative Pain Relief in Mandibular Third Molar Extractions
Who cites it
11 citing papers in PubMed, 40 citations in OpenAlex.
- Does Liposomal Bupivacaine Reduce Postoperative Pain Following Third Molar Extractions? A Double-Blinded Randomized Controlled Trial.Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons · 2025Trial
- Efficacy of Liposomal Bupivacaine in Third Molar Extraction: A Systematic Review and Meta-Analysis.Cureus · 2026Review
- Education regarding opioid prescription within oral and maxillofacial surgery residency programs: a survey study.Journal of dental anesthesia and pain medicine · 2025Article
- The Temporo-Masseteric Nerve Block (TMNB) for Alleviating Acute Postextraction Masticatory Myalgia: A Case Series.Anesthesia progress · 2025Article
- Examining Liposomal Bupivacaine's Use in Dentistry.Anesthesia progress · 2024Article
- Advances in the use of local anesthetic extended-release systems in pain management.Drug delivery · 2024Review
- Considerations for Satisfactory Sedation during Dental Implant Surgery.Journal of personalized medicine · 2023Review
- Assessing the Effectiveness of Combined Analgesics for Bilateral Ramus Osteotomies.Anesthesia progress · 2020Observational
- Nonsteroidal Anti-Inflammatory Drugs and Opioids in Postsurgical Dental Pain.Journal of dental research · 2020Article
- The Role of Exparel Plus Meloxicam for Postoperative Pain Management.Current pain and headache reports · 2020Review
- Association of Opioid Prescriptions From Dental Clinicians for US Adolescents and Young Adults With Subsequent Opioid Use and Abuse.JAMA internal medicine · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The analgesic efficacy and safety of liposomal bupivacaine (LB) in third molar extraction was evaluated in this phase 3, double-blind, placebo-controlled study of subjects undergoing bilateral third molar extraction. Subjects were randomized 2 : 1 to infiltration with LB (133 mg/10 mL) or placebo, and received opioid rescue medication as needed. Primary efficacy measure was cumulative area under the curve (AUC) of numeric rating scale (NRS) pain severity scores through 48 hours (AUC of NRS
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.