ArticleProceedings of the National Academy of Sciences of the United States of America1987
Alpha-chain locus of the T-cell antigen receptor is involved in the t(10;14) chromosome translocation of T-cell acute lymphocytic leukemia.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1987. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed, 48 citations in OpenAlex.
- Atrx inactivation drives disease-defining phenotypes in glioma cells of origin through global epigenomic remodeling.Nature communications · 2018Article
- V(D)J Recombination: Mechanism, Errors, and Fidelity.Microbiology spectrum · 2014Review
- HOX11, a homeobox-containing T-cell oncogene on human chromosome 10q24.Proceedings of the National Academy of Sciences of the United States of America · 1991Article
- Allelic loss of chromosomes 16q and 10q in human prostate cancer.Proceedings of the National Academy of Sciences of the United States of America · 1990Article
- The t(10;14)(q24;q11) of T-cell acute lymphoblastic leukemia juxtaposes the delta T-cell receptor with TCL3, a conserved and activated locus at 10q24.Proceedings of the National Academy of Sciences of the United States of America · 1990Article
- The tal gene undergoes chromosome translocation in T cell leukemia and potentially encodes a helix-loop-helix protein.The EMBO journal · 1990Article
- Alternating purine-pyrimidine tracts may promote chromosomal translocations seen in a variety of human lymphoid tumours.The EMBO journal · 1989Article
- Clustering of breakpoints on chromosome 10 in acute T-cell leukemias with the t(10;14) chromosome translocation.Proceedings of the National Academy of Sciences of the United States of America · 1989Article
- Molecular analysis of a t(14;14) translocation in leukemic T-cells of an ataxia telangiectasia patient.Proceedings of the National Academy of Sciences of the United States of America · 1989Article
- Breakage of the T cell receptor alpha chain locus in non malignant clones from patients with ataxia telangiectasia.Human genetics · 1988Article
- Cloning of the gene encoding the delta subunit of the human T-cell receptor reveals its physical organization within the alpha-subunit locus and its involvement in chromosome translocations in T-cell malignancy.Proceedings of the National Academy of Sciences of the United States of America · 1988Article
- Article
- The mechanism of chromosomal translocation t(11;14) involving the T-cell receptor C delta locus on human chromosome 14q11 and a transcribed region of chromosome 11p15.The EMBO journal · 1988Article
- Genetic and cytogenetic changes in acute lymphoblastic leukemia.Medical oncology and tumor pharmacotherapy · 1988Review
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
Human leukemic T cells carrying a t(10;14)(q24;q11) chromosome translocation were fused with mouse leukemic T cells, and the hybrids were examined for genetic markers of human chromosomes 10 and 14. Hybrids containing the human 10q+ chromosome had the human genes for terminal deoxynucleotidyltransferase that has been mapped at 10q23-q25 and for C alpha [the constant region of TCRA (the alpha-chain locus of the T-cell antigen receptor gene)], but not for V alpha (the variable region of TCRA). Hybrids containing the human 14q- chromosome retained the V alpha genes. Thus the 14q11 breakpoint in the t(10;14) chromosome translocation directly involves TCRA, splitting the locus in a region between the V alpha and the C alpha genes. These results suggest that the translocation of the C alpha locus to a putative cellular protooncogene located proximal to the breakpoint at 10q24, for which we propose the name TCL3, results in its deregulation, leading to T-cell leukemia. Since hybrids with the 10q+ chromosome also retained the human terminal deoxynucleotidyltransferase gene, it is further concluded that the terminal deoxynucleotidyltransferase locus is proximal to the TCL3 gene, at band 10q23-q24.
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