ArticlePflugers Archiv : European journal of physiology1987
A study of the post-tetanic twitch depression at the prostatic end of the rat vas deferens.
Article in Pflugers Archiv : European journal of physiology, 1987. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed, 4 citations in OpenAlex.
- The temperature sensitivity of motor units in rat soleus.Scientific reports · 2024Article
- The fade of the purinergic neurogenic contraction of the guinea-pig vas deferens: analysis of possible mechanisms.Naunyn-Schmiedeberg's archives of pharmacology · 1994Article
- Physiology of the vas deferens.World journal of urology · 1994Review
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The effects of different drugs on the post-tetanic twitch responses of the prostatic end of the isolation rat vas deferens were examined. Following repetitive field stimulation (4-5 Hz for 40-60 s), the post-tetanic twitches (0.2-0.5 Hz) were depressed relative to the steady-state pretetanic twitches. Maximum post-tetanic twitch depression (PTD) occurred 15-30 s after the tetanic stimulation. The PTD was not reversed but deepened and prolonged by the presynaptic alpha 2-adrenoceptor antagonists idazoxan (RX781094) or yohimbine (10(-7) M) alone or combined with the neuronal uptake blocker, desipramine (10(-6) M). The PTD was insensitive to the beta-adrenoceptor blocker, propranolol (10(-6) M), the P1-purinoceptor antagonist, 8-phenyltheophylline (10(-5) M) or the prostaglandin E synthesis inhibitor, indomethacin (10(-6) M). Pre- and post-tetanic contractions to superfused noradrenaline (NA), adenosine 5'-triphosphate (ATP), or beta, gamma-methylene ATP (beta, gamma-mATP) (bolus injections into superfusate, 1-8 X 10(-5) M) were not significantly (p less than 0.01) different. The PTD was absent in high magnesium (6.2-11.2 mM) solutions. These results are consistent with the PTD having an intrinsic presynaptic origin. They are discussed in relation to stimulation-induced modulation of transmitter release.
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