ArticleASAIO journal (American Society for Artificial Internal Organs : 1992)
Combined In Silico and In Vitro Approach Predicts Low Wall Shear Stress Regions in a Hemofilter that Correlate with Thrombus Formation In Vivo.
Article in ASAIO journal (American Society for Artificial Internal Organs : 1992). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Design and Implementation of a Universal Donor Kidney.Kidney360 · 2026Review
- A Simulation-Based Comparison of Human, Porcine and Ovine Pulmonary Artery Hemodynamics. Evaluating the Suitability of Large Animal Models for Endopulmonary Device Evaluation from a Hemodynamics Point of View.Cardiovascular engineering and technology · 2025Article
- 3D Membrane Microstructures for Increased Efficiency in Blood-Gas Transfer.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- A silicon membrane microfluidic oxygenator for use as an artificial placenta with minimal anticoagulation.Bioengineering & translational medicine · 2025Article
- Translation of Animal Study to Human: In Silico Based Development of Implantable Pulmonary Artery Pressure Sensor.International journal for numerical methods in biomedical engineering · 2025Article
- Integrated multidisciplinary approach to aneurysm hemodynamic analysis: numerical simulation,Frontiers in bioengineering and biotechnology · 2025Review
- Flow Dynamic Factors Correlated With Device-Related Thrombosis After Left Atrial Appendage Occlusion.JACC. Advances · 2024Article
- Hemodynamic changes for half cover left subclavian artery ostium during thoracic endovascular aortic repair.Frontiers in surgery · 2024Article
- Feasibility of an implantable bioreactor for renal cell therapy using silicon nanopore membranes.Nature communications · 2023Article
- In-silico enhanced animal study of pulmonary artery pressure sensors: assessing hemodynamics using computational fluid dynamics.Frontiers in cardiovascular medicine · 2023Article
- Virtual Reality Cardiac Surgical Planning Software (CorFix) for Designing Patient-Specific Vascular Grafts: Development and Pilot Usability Study.JMIR cardio · 2022Article
- Association of vortical structures and hemodynamic parameters for regional thrombus accumulation in abdominal aortic aneurysms.International journal for numerical methods in biomedical engineering · 2022Article
- Mathematical and Computational Modeling of Device-Induced Thrombosis.Current opinion in biomedical engineering · 2021Article
- Role of surgeon intuition and computer-aided design in Fontan optimization: A computational fluid dynamics simulation study.The Journal of thoracic and cardiovascular surgery · 2020Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
A major challenge in developing blood-contacting medical devices is mitigating thrombogenicity of an intravascular device. Thrombi may interfere with device function or embolize from the device to occlude distant vascular beds with catastrophic consequences. Chemical interactions between plasma proteins and bioengineered surface occur at the nanometer scale; however, continuum models of blood predict local shear stresses that lead to platelet activation or aggregation and thrombosis. Here, an iterative approach to blood flow path design incorporating in silico, in vitro, and in vivo experiments predicted the occurrence and location of thrombi in an implantable hemofilter. Low wall shear stress (WSS) regions identified by computational fluid dynamics (CFD) predicted clot formation in vivo. Revised designs based on CFD demonstrated superior performance, illustrating the importance of a multipronged approach for a successful design process.
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Registered trials
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