Evidence map›Paper›PMID 28857566›Full record

ArticleJournal of medicinal chemistry2017

Exploring Structural Parameters for Pretargeting Radioligand Optimization.

Jan-Philip Meyer, Paul Kozlowski, James Jackson, Kristen M Cunanan, Pierre Adumeau, Thomas R Dilling, Brian M Zeglis, Jason S Lewis

Open access · greenAbstract read
In one paragraph

Article in Journal of medicinal chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 68 citations in OpenAlex.

  1. Review
  2. Article
  3. Pretargeted Trop-2 ImmunoPET for Rapid, Selective Detection of Pancreatic Tumors.Clinical cancer research : an official journal of the American Association for Cancer Research · 2025
    Article
  4. Head-to-Head Comparison of theMolecular pharmaceutics · 2025
    Article
  5. Article
  6. Article
  7. Review
  8. Pretargeting with Cucurbituril-Adamantane Host-Guest Pair in Xenograft Models.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2023
    Article
  9. Synthesis and radiolabeling of a polar [Journal of labelled compounds & radiopharmaceuticals · 2023
    Article
  10. Review
  11. Review
  12. Article
  13. Article
  14. Optimization of Direct AromaticMolecules (Basel, Switzerland) · 2022
    Article
  15. Review
  16. Development ofPharmaceuticals (Basel, Switzerland) · 2022
    Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Jan-Philip MeyerDepartment of Radiology, Memorial Sloan Kettering Cancer Center , New York, New York 10065, United States.ORCID 0000-0003-4252-370X
Paul KozlowskiDepartment of Radiology, Memorial Sloan Kettering Cancer Center , New York, New York 10065, United States.
James JacksonDepartment of Radiology, Memorial Sloan Kettering Cancer Center , New York, New York 10065, United States.
Kristen M CunananDepartment of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center , New York, New York 10065, United States.
Pierre AdumeauDepartment of Chemistry, Hunter College of the City University of New York , New York, New York 10065, United States.
Thomas R DillingDepartment of Radiology, Memorial Sloan Kettering Cancer Center , New York, New York 10065, United States.
Brian M ZeglisDepartment of Radiology, Memorial Sloan Kettering Cancer Center , New York, New York 10065, United States.ORCID 0000-0002-9091-744X
Jason S LewisDepartment of Radiology, Memorial Sloan Kettering Cancer Center , New York, New York 10065, United States.
Memorial Sloan Kettering Cancer Center · USCity University of New York · USThe Graduate Center, CUNY · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
Pretargeted Radioimmunotherapy Based on Bioorthogonal Click ChemistryR00CA178205 · NCI · HUNTER COLLEGE · PI ZEGLIS, BRIAN MATTHEW · 2015 to 2017
$747k
Development of 18F-based Pretargeted PET imaging strategies for the PET imaging of cancerF32CA210396 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI MEYER, JAN-PHILIP · 2016 to 2017
$68k
NCI NIH HHS F32 CA210396NCI NIH HHS P30 CA008748NCI NIH HHS R00 CA178205
6 · The paper itself

Abstract

Pretargeting offers a way to enhance target specificity while reducing off-target radiation dose to healthy tissue during payload delivery. We recently reported the development of an

Indexed as

AnimalsDrug DiscoveryFluorine RadioisotopesHumansNeoplasmsPositron-Emission TomographyRadiometryRadiopharmaceuticalsRatsSmall Molecule LibrariesStructure-Activity RelationshipXenograft Model Antitumor AssaysFluorine RadioisotopesRadiopharmaceuticalsSmall Molecule Libraries

Identifiers

PMID28857566
PMCPMC6521719
OpenAlexW2751614520

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.