ArticleThoracic cancer2017
Effects of FSTL1 on the proliferation and motility of breast cancer cells and vascular endothelial cells.
Article in Thoracic cancer, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 23 citations in OpenAlex.
- Odd-skipped related 1 plays a tumor suppressor role in ovarian cancer via promoting follistatin-like protein 1 transcription.Human cell · 2022Article
- Hypoxia Promotes Angiogenic Effect in Extracranial Arteriovenous Malformation Endothelial Cells.International journal of molecular sciences · 2022Article
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- FSTL1 promotes growth and metastasis in gastric cancer by activating AKT related pathway and predicts poor survival.American journal of cancer research · 2021Article
- Application of electrochemical biosensors in tumor cell detection.Thoracic cancer · 2020Review
- Alteration of cell junctions during viral infection.Thoracic cancer · 2020Review
- Environmental pollutants damage airway epithelial cell cilia: Implications for the prevention of obstructive lung diseases.Thoracic cancer · 2020Review
- Structural and functional study of FK domain of Fstl1.Protein science : a publication of the Protein Society · 2019Article
- FSTL1 enhances chemoresistance and maintains stemness in breast cancer cells via integrin β3/Wnt signaling under miR-137 regulation.Cancer biology & therapy · 2019Article
- Non-canonical functions of the mitotic kinesin Eg5.Thoracic cancer · 2018Review
- Follistatin-like 1 in development and human diseases.Cellular and molecular life sciences : CMLS · 2018Review
- Exopolysaccharides from a Codonopsis pilosula endophyte activate macrophages and inhibit cancer cell proliferation and migration.Thoracic cancer · 2018Article
- Molecular mechanisms underlying stress response and adaptation.Thoracic cancer · 2018Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTreatments that prevent the motility of breast cancer cells and inhibit formation of new capillary vessels are urgently needed. FSTL1 is a secreted protein that has been implicated in maintaining the normal physiological function of the cardiovascular system, in addition to a variety of other biological functions. We investigated the role of FSTL1 in the proliferation and migration of breast cancer and vascular endothelial cells.
methodsHuman umbilical vein endothelial cells and human breast cancer BT-549 cells were used to test the effects of FSTL1 and the N-terminal domain of FSTL1. Immunofluorescence microscopy and 3-(4, 5-dimethylthiazolyl-2)-2,5-diphenyltetrazolium bromide, transwell invasion, and wound healing assays were conducted.
resultsDifferent doses of the N-terminal fragment of FSTL1 (FSTL-N) have variable effects on the migration of these cells. However, FSTL1 does not significantly affect tube formation in vitro from vascular endothelial cells. FSTL1-FL and FSTL1-N have modest effects on the invasion of breast cancer and vascular endothelial cells. Interestingly, FSTL1-FL, but not FSTL-N, modulates vascular endothelial cell polarization.
conclusionFSTL1 modestly affects the proliferation of breast cancer cells and vascular endothelial cells. Our findings improve our understanding of the functions of FSTL1 in breast cancer development and angiogenesis.
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