Evidence map›Paper›PMID 28857482›Full record

ArticleGenes, brain, and behavior2018

Dopaminergic and behavioural changes in a loss-of-imprinting model of Cdkn1c.

G I McNamara, B A Davis, M Browne, T Humby, J W Dalley, J Xia, R M John, A R Isles

Open access · hybridAbstract read
In one paragraph

Article in Genes, brain, and behavior, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
3.3field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 31 citations in OpenAlex.

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  14. Intragenomic conflict over bet-hedging.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2019
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

G I McNamaraBehavioural Genetics Group, MRC Centre for Neuropsychiatric Genetics and Genomics, Neuroscience and Mental Health Research Institute, Cardiff University, Cardiff, UK.
B A DavisSchool of Biosciences, Cardiff University, Cardiff, UK.
M BrowneSchool of Biosciences, Cardiff University, Cardiff, UK.
T HumbyBehavioural Genetics Group, MRC Centre for Neuropsychiatric Genetics and Genomics, Neuroscience and Mental Health Research Institute, Cardiff University, Cardiff, UK.
J W DalleyDepartment of Psychology, University of Cambridge, Cambridge, UK.
J XiaDepartment of Psychology, University of Cambridge, Cambridge, UK.
R M JohnSchool of Biosciences, Cardiff University, Cardiff, UK.
A R IslesBehavioural Genetics Group, MRC Centre for Neuropsychiatric Genetics and Genomics, Neuroscience and Mental Health Research Institute, Cardiff University, Cardiff, UK.ORCID 0000-0002-7587-5712
Cardiff University · GBUniversity of Cambridge · GB

Funding

Medical Research Council G0801418Medical Research Council MR/L010305/1Medical Research Council MR/M013960/1Wellcome TrustWellcome Trust WT093766MA
6 · The paper itself

Abstract

The imprinted gene Cdkn1c is expressed exclusively from the maternally inherited allele as a consequences of epigenetic regulation. Cdkn1c exemplifies many of the functional characteristics of imprinted genes, playing a role in foetal growth and placental development. However, Cdkn1c also plays an important role in the brain, being key to the appropriate proliferation and differentiation of midbrain dopaminergic neurons. Using a transgenic model (Cdkn1c

Indexed as

AnimalsBehavior, AnimalBrainCyclin-Dependent Kinase Inhibitor p57DopamineDopaminergic NeuronsGenomic ImprintingMice, Inbred C57BLMice, TransgenicPromoter Regions, GeneticProto-Oncogene Proteins c-fosCdkn1c protein, mouseCyclin-Dependent Kinase Inhibitor p57DopamineProto-Oncogene Proteins c-fosDopamineepigeneticsimprinted genesp57kip2rewardsocial dominance

Identifiers

PMID28857482
PMCPMC5836939
OpenAlexW2751630511

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.