Trial reportMicrocirculation (New York, N.Y. : 1994)2017
Effect of direct cold atmospheric plasma (diCAP) on microcirculation of intact skin in a controlled mechanical environment.
Trial report in Microcirculation (New York, N.Y. : 1994), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A dual-index framework for cold atmospheric plasma dosing: A meta-analysis of parametric control from volumetric redox flux to redox homeostatic status.Redox biology · 2026Pooled it
- A Prospective Randomized Controlled Pilot Study to Assess the Response and Tolerability of Cold Atmospheric Plasma for Rosacea.Skin pharmacology and physiology · 2023Trial
- Effect of direct cold atmospheric plasma (diCAP) on microcirculation of intact skin in a controlled mechanical environment.Microcirculation (New York, N.Y. : 1994) · 2017Trial
- Exploring Sexual Dimorphism and Genetic Variability in Cutaneous Microhemodynamics in BALB/c, C57BL/6J, and KM Mice.Journal of vascular research · 2026Article
- Reactive oxygen species in health and disease.Molecular biomedicine · 2026Review
- Penetration depth of cold atmospheric plasma into biological tissue: a review.Frontiers in bioengineering and biotechnology · 2026Review
- Hierarchical Poromechanical Approach to Investigate the Impact of Mechanical Loading on Human Skin Micro-Circulation.International journal for numerical methods in biomedical engineering · 2025Article
- Advancing chronic and acute wound healing with cold atmospheric plasma: cellular and molecular mechanisms, benefits, risks, and future directions.Frontiers in medicine · 2025Review
- Exploring the Use of Cold Atmospheric Plasma to Overcome Drug Resistance in Cancer.Biomedicines · 2023Review
- Cold Atmospheric Plasma Reduces Vessel Density and Increases Vascular Permeability and Apoptotic Cell Death in Solid Tumors.Cancers · 2022Article
- Topically Confined Enhancement of Cutaneous Microcirculation by Cold Plasma.Skin pharmacology and physiology · 2022Article
- Plasma Dermatology: Skin Therapy Using Cold Atmospheric Plasma.Frontiers in oncology · 2022Review
- Medical gas plasma-stimulated wound healing: Evidence and mechanisms.Redox biology · 2021Review
- The Response and Tolerability of a Novel Cold Atmospheric Plasma Wound Dressing for the Healing of Split Skin Graft Donor Sites: A Controlled Pilot Study.Skin pharmacology and physiology · 2021Article
- Study on Chemical Modifications of Glutathione by Cold Atmospheric Pressure Plasma (Cap) Operated in Air in the Presence of Fe(II) and Fe(III) Complexes.Scientific reports · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe microcirculatory response of intact human skin to exposure with diCAP for different durations with a focus on the effect of implied mechanical pressure during plasma treatment was investigated.
methodsLocal relative hemoglobin, blood flow velocity, tissue oxygen saturation, and blood flow were monitored noninvasively for up to 1 hour in 1-2 mm depth by optical techniques, as well as temperature, pH values, and moisture before and after skin stimulation. The experimental protocol (N = 10) was set up to differentiate between pressure- and plasma-induced effects.
resultsSignificant increases in microcirculation were only observed after plasma stimulation but not after pressure stimulus alone. For a period of 1 h after stimulation, local relative hemoglobin was increased by 5.1% after 270 seconds diCAP treatment. Tissue oxygen saturation increased by up to 9.4%, whereas blood flow was doubled (+106%). Skin pH decreased by 0.3 after 180 seconds and 270 seconds diCAP treatment, whereas skin temperature and moisture were not affected.
conclusionsdiCAP treatment of intact skin notably enhances microcirculation for a therapeutically relevant period. This effect is specific to the plasma treatment and not an effect of the applied pressure. Prolonged treatment durations lead to more pronounced effects.
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