ArticleThe New phytologist2018
Dissecting the components controlling root-to-shoot arsenic translocation in Arabidopsis thaliana.
Article in The New phytologist, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Arsenic-sensing domain controls ACR3 transporter trafficking in Marchantia polymorpha.The Plant cell · 2026Article
- Harnessing polyploidy and nitric oxide for improved arsenic tolerance in Oryza sativa.BMC plant biology · 2025Article
- PromoterEco-Environment & Health · 2025Article
- Cucurbitacin Profile and Metalloid Stress Response inPlant direct · 2025Article
- Review
- Phytoremediation of Potentially Toxic Elements: Role, Status and Concerns.Plants (Basel, Switzerland) · 2023Review
- Review
- Molecular insight into arsenic uptake, transport, phytotoxicity, and defense responses in plants: a critical review.Planta · 2022Review
- Metalloid transporters and their regulation in plants.Plant physiology · 2021Review
- Safe, efficient, and economically beneficial remediation of arsenic-contaminated soil: possible strategies for increasing arsenic tolerance and accumulation in non-edible economically important native plants.Environmental science and pollution research international · 2021Review
- Characterization and risk assessment of arsenic contamination in soil-plant (vegetable) system and its mitigation through water harvesting and organic amendment.Environmental geochemistry and health · 2021Article
- Targeted expression of the arsenate reductase HAC1 identifies cell type specificity of arsenic metabolism and transport in plant roots.Journal of experimental botany · 2021Article
- Sulphur potentiates selenium to alleviate arsenic-induced stress by modulating oxidative stress, accumulation and thiol-ascorbate metabolism in Brassica juncea L.Environmental science and pollution research international · 2020Article
- Differential responses of growth, photosynthesis, oxidative stress, metals accumulation and NRAMP genes in contrasting Ricinus communis genotypes under arsenic stress.Environmental science and pollution research international · 2019Article
- Pathways of arsenic uptake and efflux.Environment international · 2019Review
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Authors and funding
7 authors.
Funding
Abstract
Arsenic (As) is an important environmental and food-chain toxin. We investigated the key components controlling As accumulation and tolerance in Arabidopsis thaliana. We tested the effects of different combinations of gene knockout, including arsenate reductase (HAC1), γ-glutamyl-cysteine synthetase (γ-ECS), phytochelatin synthase (PCS1) and phosphate effluxer (PHO1), and the heterologous expression of the As-hyperaccumulator Pteris vittata arsenite efflux (PvACR3), on As tolerance, accumulation, translocation and speciation in A. thaliana. Heterologous expression of PvACR3 markedly increased As tolerance and root-to-shoot As translocation in A. thaliana, with PvACR3 being localized to the plasma membrane. Combining PvACR3 expression with HAC1 mutation led to As hyperaccumulation in the shoots, whereas combining HAC1 and PHO1 mutation decreased As accumulation. Mutants of γ-ECS and PCS1 were hypersensitive to As and had higher root-to-shoot As translocation. Combining γ-ECS or PCS1 with HAC1 mutation did not alter As tolerance or accumulation beyond the levels observed in the single mutants. PvACR3 and HAC1 have large effects on root-to-shoot As translocation. Arsenic hyperaccumulation can be engineered in A. thaliana by knocking out the HAC1 gene and expressing PvACR3. PvACR3 and HAC1 also affect As tolerance, but not to the extent of γ-ECS and PCS1.
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