Evidence map›Paper›PMID 28856963›Full record

ArticleThe Clinical neuropsychologist2018

Performance on a 1-week delayed recall task is associated with medial temporal lobe structures in neurologically normal older adults.

R Saloner, K B Casaletto, G Marx, S Dutt, A B Vanden Bussche, M You, E Fox, J Stiver, J H Kramer

Abstract read
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In one paragraph

Article in The Clinical neuropsychologist, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

R Salonera Department of Neurology , University of California , San Francisco , CA , USA.
K B Casalettoa Department of Neurology , University of California , San Francisco , CA , USA.
G Marxa Department of Neurology , University of California , San Francisco , CA , USA.
S Dutta Department of Neurology , University of California , San Francisco , CA , USA.
A B Vanden Busschea Department of Neurology , University of California , San Francisco , CA , USA.
M Youa Department of Neurology , University of California , San Francisco , CA , USA.
E Foxa Department of Neurology , University of California , San Francisco , CA , USA.
J Stivera Department of Neurology , University of California , San Francisco , CA , USA.
J H Kramera Department of Neurology , University of California , San Francisco , CA , USA.

Funding

PrPSc SPECIFIC INTERACTION WITH NOVEL PrP-Fc FUSION PROTEINSP50AG023501 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HUANG, YADONG · 2004 to 2018
$27.1M
Mechanisms of Executive Decline in Normal AgingR01AG032289 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Kaitlin B Casaletto, JOEL H KRAMER · 2009 to 2026
$8.3M
Effects of chronic inflammation on brain structure and functionR01AG048234 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KRAMER, JOEL H · 2015 to 2019
$3.2M
NIA NIH HHS P50 AG023501NIA NIH HHS R01 AG032289NIA NIH HHS R01 AG048234
6 · The paper itself

Abstract

objectiveTraditional episodic memory tests employ a delayed recall length ranging from 10 to 30 min. The neurobiological process of memory consolidation extends well beyond these time intervals, however, raising the possibility that these tests might not be fully sensitive to the subtle neurocognitive changes found in early disease or age-related decline. We aimed to determine the sensitivity of a 1-week delayed recall paradigm to medial temporal lobe (MTL) structure among neurologically normal older adults.

methodsOne hundred and forty functionally intact, older adults (mean age = 75.8) completed a story recall test in which participants learned to 90% criterion. Recall was tested after 30-min and 1-week. Participants also completed a standardized list learning task with a 20-min delay (n = 129) and a structural brain MRI. The MTL, including the parahippocampal gyrus, hippocampus, and entorhinal, was our primary region of interest.

resultsControlling for age, education, gender and total intracranial volume, the standard 20- and 30-min recalls showed no significant relationship with MTL. In contrast, 1-week recall was uniquely associated with MTL structure (partial r = .24, p = .006), specifically entorhinal (partial r = .27; p = .001) and hippocampal (partial r = .21, p = .02) volumes.

conclusionMemory paradigms that utilize 1-week delays are more sensitive than standard paradigms to MTL volumes in neurologically normal older adults. Longer delay periods may improve detection of memory consolidation abilities associated with age-related, and potentially pathological, neurobehavioral change.

Indexed as

Memory, EpisodicAgedAged, 80 and overCognitive DysfunctionFemaleHumansMagnetic Resonance ImagingMaleMemory DisordersMental RecallMiddle AgedNeuropsychological TestsPsychomotor PerformanceTemporal LobeTime FactorsAgingAlzheimer’s diseaseentorhinal cortexhippocampusmemory consolidation

Identifiers

PMID28856963
PMCPMC5832581

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.