ArticleThe Journal of comparative neurology2017
The transcription factor Phox2b distinguishes between oral and non-oral sensory neurons in the geniculate ganglion.
Article in The Journal of comparative neurology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 35 citations in OpenAlex.
- Anatomical Characteristics of Tongue-Innervating Mechanoreceptors.The Journal of comparative neurology · 2026Article
- Ribosomal Profiling of the Geniculate Ganglion Identifies the Receptor ALK as Critical for the Development and Maintenance of Oral Sensory Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Response characteristics of oral mechanosensory neurons in the mouse trigeminal ganglion.Chemical senses · 2025Article
- Deciphering Peripheral Taste Neuron Diversity: Using Genetic Identity to Bridge Taste Bud Innervation Patterns and Functional Responses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Trigeminal innervation and tactile responses in mouse tongue.Cell reports · 2024Article
- The differences in the anatomy of the thoracolumbar and sacral autonomic outflow are quantitative.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2024Review
- Give-and-take of gustation: the interplay between gustatory neurons and taste buds.Chemical senses · 2024Review
- Cyclophosphamide induces the loss of taste bud innervation in mice.Chemical senses · 2024Article
- Prdm12 represses the expression of the visceral neuron determinants Phox2a/b in developing somatosensory ganglia.iScience · 2023Article
- Rapid structural remodeling of peripheral taste neurons is independent of taste cell turnover.PLoS biology · 2023Article
- Taste arbor structural variability analyzed across taste regions.The Journal of comparative neurology · 2023Article
- Variable Branching Characteristics of Peripheral Taste Neurons Indicates Differential Convergence.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Onset of taste bud cell renewal starts at birth and coincides with a shift in SHH function.eLife · 2021Article
- The Fungiform Papilla Is a Complex, Multimodal, Oral Sensory Organ.Current opinion in physiology · 2021Article
- Whole-Mount Staining, Visualization, and Analysis of Fungiform, Circumvallate, and Palate Taste Buds.Journal of visualized experiments : JoVE · 2021Article
- Cell non-autonomous requirement of p75 in the development of geniculate oral sensory neurons.Scientific reports · 2020Article
- Genetic Deletion of TrpV1 and TrpA1 Does Not Alter Avoidance of or Patterns of Brainstem Activation to Citric Acid in Mice.Chemical senses · 2020Article
- Selective Peripheral Taste Dysfunction in APP/PS1 Mutant Transgenic Mice.Journal of Alzheimer's disease : JAD · 2020Article
- Vertebrate Sensory Ganglia: Common and Divergent Features of the Transcriptional Programs Generating Their Functional Specialization.Frontiers in cell and developmental biology · 2020Review
- TrkB expression and dependence divides gustatory neurons into three subpopulations.Neural development · 2019Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Many basic characteristics of gustatory neurons remain unknown, partly due to the absence of specific markers. Some neurons in the geniculate ganglion project to taste regions in the oral cavity, whereas others innervate the outer ear. We hypothesized that the transcription factor Phox2b would identify oral cavity-projecting neurons in the geniculate ganglion. To test this possibility, we characterized mice in which Phox2b-Cre mediated gene recombination labeled neurons with tdTomato. Nerve labeling revealed that all taste neurons projecting through the chorda tympani (27%) and greater superficial petrosal nerves (15%) expressed Phox2b during development, whereas non-oral somatosensory neurons (58%) in the geniculate ganglion did not. We found tdTomato-positive innervation within all taste buds. Most (57%) of the fungiform papillae had labeled innervation only in taste buds, whereas 43% of the fungiform papillae also had additional labeled innervation to the papilla epithelium. Chorda tympani nerve transection eliminated all labeled innervation to taste buds, but most of the additional innervation in the fungiform papillae remained. Some of these additional fibers also expressed tyrosine hydroxylase, suggesting a sympathetic origin. Consistent with this, both sympathetic and parasympathetic fibers innervating blood vessels and salivary glands contained tdTomato labeling. Phox2b-tdTomato labels nerve fascicles in the tongue of the developing embryo and demonstrates a similar stereotyped branching pattern DiI-labeling.
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