ArticleEuropean child & adolescent psychiatry2018
Dosage of methylphenidate and traumatic brain injury in ADHD: a population-based study in Taiwan.
Article in European child & adolescent psychiatry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- Risks and Benefits of Attention-Deficit/Hyperactivity Disorder Medication on Behavioral and Neuropsychiatric Outcomes: A Qualitative Review of Pharmacoepidemiology Studies Using Linked Prescription Databases.Biological psychiatry · 2019Pooled it
- Effect of ADHD medication on risk of injuries: a preference-based instrumental variable analysis.European child & adolescent psychiatry · 2024Article
- Lifetime history of concussion among children and adolescents with attention-deficit/hyperactivity disorder: examining differences stratified by age, medication status, and parent-reported severity.Frontiers in neurology · 2024Article
- Methylphenidate and TBI in ADHD and co-occurring epilepsy and mental disorders: a self-controlled case series study.European child & adolescent psychiatry · 2022Article
- Concussion Incidence and Recovery Among Youth Athletes With ADHD Taking Stimulant-Based Therapy.Orthopaedic journal of sports medicine · 2021Article
- The World Federation of ADHD International Consensus Statement: 208 Evidence-based conclusions about the disorder.Neuroscience and biobehavioral reviews · 2021Review
- Association of psychiatric comorbidities with the risk of transport accidents in ADHD and MPH.Epidemiology and psychiatric sciences · 2021Article
- Methylphenidate Use and Infectious Diseases in Children With Attention Deficit and Hyperactivity Disorder: A Population-Based Study.Frontiers in medicine · 2021Article
- Methylphenidate and the risk of burn injury among children with attention-deficit/hyperactivity disorder.Epidemiology and psychiatric sciences · 2020Article
- Decreased Risk of Influenza in Child and Adolescent Patients with Attention-Deficit Hyperactivity Disorder Following Methylphenidate Treatment: A Nationwide Cohort Study in Taiwan.Neuropsychiatric disease and treatment · 2020Article
- Attention-Deficit/Hyperactivity Disorder and Mortality Risk in Taiwan.JAMA network open · 2019Article
- Treatment strategies for ADHD: an evidence-based guide to select optimal treatment.Molecular psychiatry · 2019Review
- The Association Between Attention-Deficit Hyperactivity Disorder, Injuries, and Methylphenidate.Global pediatric health · 2019Article
- Towards a better understanding of the many facets of attention-deficit/hyperactivity disorder.European child & adolescent psychiatry · 2018Article
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Authors and funding
9 authors at 8 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Preventive effect of stimulants on the risk of brain injuries had been reported. The aim of this study is to determine the extent to which methylphenidate (MPH) prescription moderates the risk of traumatic brain injuries (TBI) in individuals with attention-deficit/hyperactivity disorder (ADHD). Individuals with a recent diagnosis of ADHD between January 1997 and December 2013 (n = 163,618) were identified from Taiwan's National Health Insurance Research Database. A total of 124,438 adolescents and children with ADHD and without prior TBI diagnoses were included and evaluated for subsequent TBI. Methylphenidate prescription duration was subgrouped by the annual average cumulative defined daily dose (DDD): 0, >0 to ≤28, > 28 to ≤84, and >84. We identified 11,463 diagnoses of TBI among 124,438 adolescents and children with ADHD. A Cox regression model was used to investigate whether MPH prescription influenced the risk for TBI after adjusting for sex, age, level of urbanization, seizure, autism and sedative-anxiolytics use. A reduced TBI incidence was observed with MPH prescription DDDs > 84. The protective effect of MPH against TBI persisted after adjusting for confounding factors [hazard ratio (HR) = 0.49; 95% confidence interval (CI): 0.47-0.51]. There was also statistically significant difference in risk for TBI in subjects receiving > 0 to ≤28 or >28 to ≤84 DDDs of MPH treatment (HR = 0.88, 95% CI = 0.83-0.92; HR = 0.76, 95% CI = 0.72-0.80, respectively) when compared with subjects not receiving treatment with MPH. Treatment with MPH for greater than 84 DDDs reduced the risk for TBI among children with ADHD.
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