ArticleClinical research in cardiology : official journal of the German Cardiac Society2017
Circadian rhythm of blood cardiac troponin T concentration.
Article in Clinical research in cardiology : official journal of the German Cardiac Society, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 57 citations in OpenAlex.
- High-Sensitivity Cardiac Troponin After Cardiac Stress Test: A Systematic Review and Meta-Analysis.Journal of the American Heart Association · 2019Pooled it
- Circadian troponin dynamics reveal sex-specific signals for acute coronary syndrome evaluation.Internal and emergency medicine · 2026Article
- Research progress of circadian rhythm in cardiovascular disease: A bibliometric study from 2002 to 2022.Heliyon · 2024Review
- Motivation states to move, be physically active and sedentary vary like circadian rhythms and are associated with affect and arousal.Frontiers in sports and active living · 2023Article
- Cardiotoxicity as a Possible Side Effect of Statins.Reviews in cardiovascular medicine · 2023Review
- Review of Recent Laboratory and Experimental Data on Cardiotoxicity of Statins.Journal of cardiovascular development and disease · 2022Review
- Hypertension as One of the Main Non-Myocardial Infarction-Related Causes of Increased Cardiospecific Troponins: From Mechanisms to Significance in Current Medical Practice.Journal of clinical medicine research · 2022Review
- Cardiac Troponins as Biomarkers of Cardiac Myocytes Damage in Case of Arterial Hypertension: From Pathological Mechanisms to Predictive Significance.Life (Basel, Switzerland) · 2022Review
- Biology of Cardiac Troponins: Emphasis on Metabolism.Biology · 2022Review
- Metabolic Pathway of Cardiospecific Troponins: From Fundamental Aspects to Diagnostic Role (Comprehensive Review).Frontiers in molecular biosciences · 2022Review
- Circadian Dependence of the Acute Immune Response to Myocardial Infarction.Frontiers in pharmacology · 2022Article
- The Importance of Cardiac Troponin Metabolism in the Laboratory Diagnosis of Myocardial Infarction (Comprehensive Review).BioMed research international · 2022Review
- Perioperative changes in cardiac biomarkers in juvenile cats during neutering.Frontiers in veterinary science · 2022Article
- A SAS macro for modelling periodic data using cosinor analysis.Computer methods and programs in biomedicine · 2021Article
- [Troponin elevation-does every patient require coronary angiography?]Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2020Review
- Preanalytical sample handling recommendations for Alzheimer's disease plasma biomarkers.Alzheimer's & dementia (Amsterdam, Netherlands) · 2019 · on this mapArticle
- Circadian rhythms and the molecular clock in cardiovascular biology and disease.Nature reviews. Cardiology · 2019Review
- Repeat Measurements of High Sensitivity Troponins for the Prediction of Recurrent Cardiovascular Events in Patients With Established Coronary Heart Disease: An Analysis From the KAROLA Study.Journal of the American Heart Association · 2019Article
- Invasive hemodynamics and cardiac biomarkers to predict outcomes after percutaneous edge-to-edge mitral valve repair in patients with severe heart failure.Clinical research in cardiology : official journal of the German Cardiac Society · 2019Article
- Plasma FGF23 does not rise during physical exercise as a physiological model of sympathetic activation.Clinical research in cardiology : official journal of the German Cardiac Society · 2019Article
Corrections and comments
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Authors and funding
15 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionHigh-sensitivity cardiac troponin assays have significantly improved the sensitivity of myocardial infarction detection by using cutoff values and early absolute changes. However, variation in repeated measures also depends on biological variability. This study aimed to assess the potential circadian component of this biological variability.
methods17 healthy volunteers were recruited, and standardized conditions for physical activity, meals, exposure to light and duration of sleep were imposed. Blood samples were collected every 4 h and high-sensitivity troponin T assay with a limit of detection of 3 ng/l and a 99th percentile of 14 ng/l were used. Circadian variations were analyzed using the cosinor method.
resultsStatistically significant circadian variations were observed for body temperature, heart rate, and systolic/diastolic arterial blood pressures (p < 0.01 using both a non-adjusted cosinor model and a gender- and BMI-adjusted cosinor model). The amplitudes of the circadian variations were 18.93, 6, 15.35, and 1.92%, respectively. A statistically significant circadian biological variation of troponin blood concentrations was evidenced (p < 0.01 in both the non-adjusted cosinor model and the gender- and BMI-adjusted cosinor), with an amplitude of 20.5% (average: 4.39 ng/l; amplitude: 0.9 ng/l; peak at 06:00 and nadir at 18:00). DISCUSSION: This study demonstrates a circadian biological variation in blood troponin concentration in a healthy population. The amplitude of this variation challenges the cutoff value for instant rule-out of the rapid rule-in/rule-out of the recent European guidelines for the management of acute coronary syndromes. These findings deserve further investigation in a population at risk of myocardial infarction.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.