Evidence map›Paper›PMID 28856439›Full record

ArticleEuropean journal of nutrition2018

Plasma amino acids, adiposity, and weight change after gastric bypass surgery: are amino acids associated with weight regain?

Susanna E Hanvold, Kathrine J Vinknes, Nasser E Bastani, Cheryl Turner, Elin B Løken, Tom Mala, Helga Refsum, Anne-Marie Aas

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In one paragraph

Article in European journal of nutrition, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Susanna E HanvoldSection of Nutrition and Dietetics, Division of Medicine, Department of Clinical Service, Oslo University Hospital Aker, Oslo, Norway. susanna@hanvold.no.
Kathrine J VinknesDepartment of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway.
Nasser E BastaniDepartment of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway.
Cheryl TurnerDepartment of Pharmacology, University of Oxford, Oxford, UK.
Elin B LøkenDepartment of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway.
Tom MalaDivision of Medicine, Department of Morbid Obesity and Bariatric Surgery, Oslo University Hospital Aker, Oslo, Norway.
Helga RefsumDepartment of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway.
Anne-Marie AasSection of Nutrition and Dietetics, Division of Medicine, Department of Clinical Service, Oslo University Hospital Aker, Oslo, Norway.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposePlasma concentrations of several amino acids (AAs) are positively correlated with obesity. The aim of this study was to examine if selected plasma AAs are associated with weight regain from 2 to 4 years after Roux-en-Y gastric bypass (RYGB).

methodsIn a prospective study with 165 patients, we examined the relationship between plasma aromatic AAs (AAAs), branched chain AAs (BCAAs), and total cysteine (tCys) 2 years after RYGB, with BMI at 2 years and with weight change from 2 to 4 years after surgery. Analyses were adjusted for relevant covariates.

resultThe investigated AAs at 2 years correlated positively with BMI at 2 years (P ≤ 0.003 for all). BCAAs and AAAs at 2 years correlated inversely with % weight loss from 0 to 2 years (P = 0.002 and P = 0.001, respectively), while the association was not significant for tCys (r = -0.14, P = 0.08). Plasma tCys at 2 years correlated positively with BMI at 4 years (P = 0.010) and with weight regain from 2 to 4 years (P = 0.015).

conclusionPlasma AAAs, BCAAs, and tCys at 2 years were associated with BMI at 2 years. In addition, plasma AAAs and BCAAs at 2 years were associated with weight loss from 0 to 2 years, while tCys at 2 years was associated with weight regain from 2 to 4 years after RYGB. These results suggest that high tCys at 2 years may be used as a prognostic marker for future weight regain. The study was registered in ClinicalTrials.gov (NCT0 1270451).

Indexed as

Gastric BypassWeight GainAdiposityAmino AcidsHumansObesityProspective StudiesWeight LossAmino AcidsAromatic amino acidsBMIBranched chain amino acidsGastric bypassPlasma amino acidsProspective studyTotal cysteineWeight change

Identifiers

PMID28856439

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.