Evidence map›Paper›PMID 28856435›Full record

Trial reportInternational orthopaedics2017

Viscosupplementation in patients with severe osteoarthritis of the knee: six month follow-up of a randomized, double-blind clinical trial.

André Luiz Siqueira Campos, Rodrigo Satamini Pires E Albuquerque, Edmilson Barbosa da Silva, Sami Gobbi Fayad, Lucas Delunardo Acerbi, Felipe Nunes de Almeida, Nelson Hiroyuki Myiabe Ooka, José Sergio Franco, Vinícius Schott Gameiro

Abstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in International orthopaedics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  7. Medial unicondylar knee arthroplasty should be reserved for patients with complete joint space collapse.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2022
    Article
  8. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

André Luiz Siqueira CamposOrthopedics Department, Hospital Federal dos Servidores do Estado do Rio de Janeiro, Rio de Janeiro, RJ, Brazil. andresiqueiracampos@hotmail.com.ORCID 0000-0002-9400-4023
Rodrigo Satamini Pires E AlbuquerqueDepartment of General and Specialized Surgery, Universidade Federal Fluminense (UFF), Niterói, RJ, Brazil.
Edmilson Barbosa da SilvaOrthopedics Department, Hospital Federal dos Servidores do Estado do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
Sami Gobbi FayadOrthopedics Department, Hospital Federal dos Servidores do Estado do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
Lucas Delunardo AcerbiOrthopedics Department, Hospital Federal dos Servidores do Estado do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
Felipe Nunes de AlmeidaOrthopedics Department, Hospital Federal dos Servidores do Estado do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
Nelson Hiroyuki Myiabe OokaOrthopedics Department, Hospital Federal dos Servidores do Estado do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
José Sergio FrancoOrthopedics Department, Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, Brazil.
Vinícius Schott GameiroDepartment of General and Specialized Surgery, Universidade Federal Fluminense (UFF), Niterói, RJ, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo analyze the early outcomes of viscosupplementation in patients with severe knee osteoarthritis.

methodA randomized, double-blind clinical trial of 143 knees divided into three groups: Group 1 - intra-articular injection of triamcinolone; Group 2 - hylan GF20; and Group 3 - triamcinolone + hylan GF20. Outcomes were evaluated using Lysholm and KSS scores before treatment and after one, three and six months.

resultsWithin-group comparisons revealed improvements in Lysholm scores in all groups in the one month evaluation relative to pre-treatment levels (p < 0.01). This improvement was maintained in the third month after treatment (p > 0.05). Scores at six months were significantly lower than those observed in the previous follow-up assessments (p < 0.05), but still higher than pre-treatment levels (p < 0.05). KSS scores also improved after one month relative to pre-treatment levels (p < 0.01). This improvement was still present at three and six months after treatment in the corticosteroid group (p > 0.05). Patients treated with hylan GF20 showed lower scores in the last evaluation relative to month one (p < 0.05). No significant differences were observed between the treatment groups (p > 0.05).

conclusionsViscosupplementation increased functional scores in patients with severe osteoarthritis of the knee, especially within three months of injection. However, it was not superior to the use of triamcinolone.

Indexed as

Double-Blind MethodFemaleFollow-Up StudiesGlucocorticoidsHumansHyaluronic AcidInjections, Intra-ArticularKnee JointMaleOsteoarthritis, KneeTreatment OutcomeTriamcinoloneViscosupplementationViscosupplementsGlucocorticoidsHyaluronic AcidhylanTriamcinoloneViscosupplementsKneeOsteoarthritisTreatmentViscosupplementation

Identifiers

PMID28856435

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.