ArticleChronic stress (Thousand Oaks, Calif.)
Neurobiological and Systemic Effects of Chronic Stress.
Article in Chronic stress (Thousand Oaks, Calif.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04129632 (Evaluation of Institutional Job Demands-Resources and a Novel Mindfulness Tool on Burnout Intensity in a Cross-sectional Cohort of Colorado Health Care Practitioners), which is not on this map. Cited by 477 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Evaluation of Institutional Job Demands-Resources and a Novel Mindfulness Tool on Burnout Intensity in a Cross-sectional Cohort of Colorado Health Care Practitioners
Who cites it
477 citing papers in PubMed, 6 syntheses or guidelines pooled it, 924 citations in OpenAlex.
- Pooled it
- Pooled it
- Comparative efficacy of mind-body exercises on quality of life, anxiety, and depression in patients with breast cancer: a systematic review with pairwise and network meta-analysis of randomized controlled trials.Frontiers in public health · 2026Pooled it
- An Overview of Stress Analysis Based on Physiological Signals: Systematic Review of Open Datasets and Current Trends.Sensors (Basel, Switzerland) · 2025Pooled it
- Exposure to community violence and biomarkers of allostatic load: A systematic review and meta-analysis.Psychological bulletin · 2025Pooled it
- Chronic stress in relation to clinical burnout: an integrative scoping review of definitions and measurement approaches.Frontiers in psychology · 2025Pooled it
- Effects of taVNS on physiological responses and cognitive performance during a mental stressor.Cognitive, affective & behavioral neuroscience · 2025Trial
- Psychobiotics Ameliorate Depression and Anxiety Status in Surgical Oncology Patients: Results from theNutrients · 2025Trial
- The benefits of mindfulness training for momentary mindfulness and emotion regulation: A randomized controlled trial for adolescents exposed to chronic stressors.Journal of consulting and clinical psychology · 2024Trial
- Stress grounded in experiences of racial discrimination: a cluster analysis among a racially diverse sample in Canada.European journal of psychotraumatology · 2026Article
- Modelling post-traumatic stress disorder-major depressive disorder comorbidity in rats: impaired α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor signalling is consistent with synergistic behavioural and cognitive deficits.European journal of psychotraumatology · 2026Article
- School Health Promotion Through UNESCO's Four Pillars of Education and NICE Participation Frameworks: A Systematic Review.Journal of prevention (2022) · 2026Review
- Child Health Challenges, Ecosystem Mismatches, and the Case for State-Level Policy Innovation.The Milbank quarterly · 2026Article
- Blunted diurnal cortisol slope as a risk marker for 9-year executive function decline: amplification by daily stress and worry severity.The journals of gerontology. Series B, Psychological sciences and social sciences · 2026Article
- Stress, needs, and behaviour: understanding chronic stress in pet domestic dogs (Canis lupus familiaris) from the prism of needs.Biological reviews of the Cambridge Philosophical Society · 2026Review
- Psychological Adaptation During Prolonged War-Related Stress in Ukraine: A Narrative Review.Health science reports · 2026Article
- Recovery from disorders of consciousness: Lesions and GABAergic modulation in a biologically inspired spiking neural network.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Next-Generation Adaptogens: Molecular Mechanisms, Bioactive Compounds and Human Health Relevance of Selected Botanicals and Fungi.International journal of molecular sciences · 2026Review
- Prior trauma shapes the effects of psilocybin on stress sensitization in mice.Neuroscience letters · 2026Article
- Review
417 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
The brain is the central organ of stress and adaptation to stress because it perceives and determines what is threatening, as well as the behavioral and physiological responses to the stressor, which promote adaptation ("allostasis") but also contribute to pathophysiology ("allostatic load/overload") when overused and dysregulated. The adult as well as developing brain possesses a remarkable ability to show structural and functional plasticity in response to stressful and other experiences, including neuronal replacement, dendritic remodeling and synapse turnover. Stress can cause an imbalance of neural circuitry subserving cognition, decision making, anxiety and mood that can increase or decrease expression of those behaviors and behavioral states. This imbalance, in turn, affects systemic physiology via neuroendocrine, autonomic, immune and metabolic mediators. In the short term, these changes may be adaptive; but, if the threat passes and the behavioral state persists along with the changes in neural circuitry, such maladaptation requires intervention with a combination of pharmacological and behavioral therapies. There are important sex differences in how the brain responds to stressors. Moreover, adverse early life experience, interacting with alleles of certain genes, produces lasting effects on brain and body via epigenetic mechanisms. While prevention is key, the plasticity of the brain gives hope for therapies that utilize brain-body interactions. Policies of government and the private sector are important to promote health and increase "healthspan."
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.