Evidence map›Paper›PMID 28856250›Full record

ArticleClinical and experimental hepatology2015

Impact of rs12979860 polymorphism on liver morphology in chronic HCV infection.

Tadeusz Wojciech Łapiński, Magdalena Rogalska-Płonska, Anatol Panasiuk, Oksana Kowalczuk, Jacek Nikliński, Robert Flisiak

Abstract read
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Article in Clinical and experimental hepatology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Tadeusz Wojciech ŁapińskiDepartment of Infectious Diseases and Hepatology, Medical University of Bialystok, Bialystok, Poland.
Magdalena Rogalska-PłonskaDepartment of Infectious Diseases and Hepatology, Medical University of Bialystok, Bialystok, Poland.
Anatol PanasiukDepartment of Infectious Diseases and Hepatology, Medical University of Bialystok, Bialystok, Poland.
Oksana KowalczukDepartment of Clinical Molecular Biology, Medical University of Bialystok, Bialystok, Poland.
Jacek NiklińskiDepartment of Clinical Molecular Biology, Medical University of Bialystok, Bialystok, Poland.
Robert FlisiakDepartment of Infectious Diseases and Hepatology, Medical University of Bialystok, Bialystok, Poland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aim of the studyTo determine distribution of rs12979860 genotypes, their correlations with viral load as well as inflammatory activity and stage of liver fibrosis in patients infected with HCV genotype 1. MATERIAL AND

methodsThe study included 132 patients infected with HCV genotype 1b. Serum viral loads were obtained with the PCR method. Rs12979860 polymorphisms were determined by sequencing of PCR products. Liver biopsy was performed in all patients.

resultsCT, TT and CC alleles of rs12979860 polymorphism were detected in 58%, 20% and 22% of patients respectively. The highest viral load was observed in the TT and the lowest in the CC group (72.0 × 10

conclusionsThere is an association between HCV viral load and rs12979860 polymorphism. Inflammatory activity and stage of liver fibrosis depend on age, but there is no relationship with rs12979860 genotypes and HCV viral load.

Indexed as

HCVliver histologypolymorphism rs12979860

Identifiers

PMID28856250
PMCPMC5421166

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