ArticlePractical laboratory medicine2017
Frequency and causes of lipemia interference of clinical chemistry laboratory tests.
Article in Practical laboratory medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 59 citations in OpenAlex.
- Article
- Lipemia and its associations with liver disease and dyslipidemia: a cross-sectional study.Lipids in health and disease · 2025Article
- Standardising lipid testing and reporting in the United Kingdom; a joint statement by HEART UK and The Association for Laboratory Medicine.Annals of clinical biochemistry · 2025Review
- Hyponatremia with an Osmolar Gap, Pseudohyponatremia or Hyper-Osmolar Hyponatremia?American journal of medicine open · 2025Article
- Impact of Drugs Used in Intensive Care on Routine Coagulation Testing.Diagnostics (Basel, Switzerland) · 2025Review
- Hemolysis, icterus and lipemia interfere with the determination of two oxidative stress biomarkers in canine serum.BMC veterinary research · 2023Article
- Article
- Handling of lipemic samples in the clinical laboratory.Advances in laboratory medicine · 2023Article
- Evaluation of hematological, biochemical and oxidative stress profile in calves under propofol anesthesia.Veterinary research communications · 2022Article
- The incidence rate and influence factors of hemolysis, lipemia, icterus in fasting serum biochemistry specimens.PloS one · 2022Article
- Frequency of icteric interference in clinical chemistry laboratory tests and causes of severe icterus.Practical laboratory medicine · 2021Article
- Variable Creatinine Levels in Critical Care Patients: A Concerning Knowledge Gap.Journal of clinical medicine · 2021Article
- Article
- Evaluation of switch from satellite laboratory to central laboratory for testing of intraoperative parathyroid hormone.Practical laboratory medicine · 2020Article
- Article
- Review of interference indices in body fluid specimens submitted for clinical chemistry analyses.Practical laboratory medicine · 2020Article
- Lipemia Interferences in Biochemical Tests, Investigating the Efficacy of Different Removal Methods in comparison with Ultracentrifugation as the Gold Standard.Journal of analytical methods in chemistry · 2020Article
- Article
- Haemolysis and lipemia interfere with resistin and myeloperoxidase BioVendor ELISA assays.Biochemia medica · 2019Article
- Case report: An index of suspicion in hyponatraemia.Biochemia medica · 2019Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThe aims of this study were to identify the causes of severe lipemia in an academic medical center patient population and to determine the relationship between lipemia and hemolysis. DESIGN AND
methodsRetrospective study was done on the data from the core clinical laboratory at an academic medical center. Lipemic indices were available for all chemistry specimens analyzed over a 16-month period (n=552,029 specimens) and for serum/plasma triglycerides concentrations ordered for clinical purposes over a 16-year period (n=393,085 specimens). Analysis was performed on Roche Diagnostics cobas 8000 analyzers. Extensive chart review was done for all specimens with lipemic index greater than 500 (severely lipemic) and for all specimens with serum/plasma triglycerides greater than 2000 mg/dL. We also determined the relationship between lipemia and hemolysis.
resultsThe most frequent suspected causes of very high lipemic index (>500) were found to be lipid-containing intravenous infusions (54.4% of total; fat emulsions for parenteral nutrition - 47%; propofol -7.4%) and diabetes mellitus (25% of total, mainly type 2). The most frequent suspected causes of very elevated serum/plasma triglycerides (>2000 mg/dL) was diabetes mellitus (64%, mainly type 2) and hyperlipidemia (16.9%). The frequency of hemolysis increased with increasing lipemic index.
conclusionsIntravenous lipid infusions and type 2 diabetes were the most common causes of severe lipemia in this study at an academic medical center. Given that iatrogenic factors are the most common cause of severe lipemia, education and intervention may be helpful in reducing frequency of severe lipemia in patient specimens.
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