ArticlePractical laboratory medicine2017
Circulating markers of ageing and allostatic load: A slow train coming.
Article in Practical laboratory medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Adverse childhood experiences, epigenetics and telomere length variation in childhood and beyond: a systematic review of the literature.European child & adolescent psychiatry · 2020Pooled it
- Eating disinhibition and vagal tone moderate the postprandial response to glycemic load: a randomised controlled trial.Scientific reports · 2016Trial
- Evidence of emerging transcriptome mediators of Alzheimer's disease in canine cognitive dysfunction.Brain pathology (Zurich, Switzerland) · 2026Article
- Cardiometabolic state links neurovascular burden with brain structure and function: Evidence from EEG and MRI.NeuroImage · 2025Article
- Development and validation of an epigenetic signature of allostatic load.Bioscience reports · 2025Article
- Emerging Theories of Allostatic-Interoceptive Overload in Neurodegeneration.Current topics in behavioral neurosciences · 2025Review
- Alzheimer's Disease and Vascular Dementia, Connecting and Differentiating Features.Current Alzheimer research · 2025Review
- Associations of three healthy dietary patterns with homeostatic dysregulation: results from the China Multi-Ethnic Cohort study.The journal of nutrition, health & aging · 2024Article
- Selected Biomarkers of Oxidative Stress and Energy Metabolism Disorders in Neurological Diseases.Molecular neurobiology · 2023Review
- Article
- A predictive coding framework of allostatic-interoceptive overload in frontotemporal dementia.Trends in neurosciences · 2022Review
- Multimorbidity.Nature reviews. Disease primers · 2022Review
- Blood-brain barrier and gut barrier dysfunction in chronic kidney disease with a focus on circulating biomarkers and tight junction proteins.Scientific reports · 2022Article
- GrimAge Outperforms Other Epigenetic Clocks in the Prediction of Age-Related Clinical Phenotypes and All-Cause Mortality.The journals of gerontology. Series A, Biological sciences and medical sciences · 2021Article
- Aging and Allostasis: Using Bayesian Network Analytics to Explore and Evaluate Allostatic Markers in the Context of Aging.Diagnostics (Basel, Switzerland) · 2021Article
- Targeting Premature Renal Aging: from Molecular Mechanisms of Cellular Senescence to Senolytic Trials.Frontiers in pharmacology · 2021Review
- Parallel Progress in Perceived Age and Life Expectancy.The journals of gerontology. Series A, Biological sciences and medical sciences · 2020Article
- Exceptionally Long-Lived Individuals (ELLI) Demonstrate Slower Aging Rate Calculated by DNA Methylation Clocks as Possible Modulators for Healthy Longevity.International journal of molecular sciences · 2020Article
- Extracellular Vesicles: Recent Developments in Aging and Reproductive Diseases.Frontiers in cell and developmental biology · 2020Review
- Fabry Disease: A New Model of Premature Ageing?Nephron · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dealing with the growing burden of age-related morbidities is one of the greatest challenges facing modern society. How we age across the lifecourse and how psychosocial and lifestyle factors interplay with the biology of ageing remains to be fully elucidated. Sensitive and specific biomarkers with which to interrogate the biology of the ageing process are sparse. Recent evidence suggests that non-coding RNAs are key determinants of such processes and that these can be used as potential circulatory bio-markers of ageing. They may also provide a mechanism which mediates the spread of allostatic load across the body over time, ultimately reflecting the immunological health and physiological status of tissues and organs. The interplay between exosomal microRNAs and ageing processes is still relatively unexplored, although circulating microRNAs have been linked to the regulation of a range of physiological and pathological processes and offer insight into mechanistic determinants of healthspan.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.