Evidence map›Paper›PMID 28856172›Full record

ArticleChild neurology open

Implementing a Multidisciplinary Approach to Treating Tuberous Sclerosis Complex: A Case Report.

Tanjala T Gipson, Andrea Poretti

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Child neurology open. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Tanjala T GipsonTuberous Sclerosis Center of Excellence, Neurology and Developmental Medicine, Kennedy Krieger Institute, Baltimore, MD, USA.
Andrea PorettiSection of Pediatric Neuroradiology, Division of Pediatric Radiology, Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Funding

NEUROLOGY SCIENCES ACADEMIC DEVELOPMENT AWARD (NSADA)K12NS001696 · NINDS · JOHNS HOPKINS UNIVERSITY · PI JOHNSTON, MICHAEL VAN DOREN · 1993 to 2016
$3.8M
NINDS NIH HHS K12 NS001696
6 · The paper itself

Abstract

objectiveTuberous sclerosis complex is expressed throughout the body, resulting in a range of clinical manifestations that can be challenging to manage.

resultsThe authors report a patient who presented at age 3.5 years with several suspected seizures and was diagnosed with tuberous sclerosis complex following the discovery of numerous bilateral cortical tubers and subependymal nodules on magnetic resonance imaging. Interdisciplinary, comprehensive care was recommended; this included ongoing surveillance to monitor for the development of tuberous sclerosis complex-associated conditions. Approximately 2 years later, the patient began exhibiting aggressive and self-injurious behavior, and a subependymal giant cell astrocytoma was discovered. After everolimus was initiated, he demonstrated less aggression, had ceased self-injurious behavior, and subependymal giant cell astrocytoma growth stabilized.

conclusionsThis case highlights the importance of a multidisciplinary approach to care in tuberous sclerosis complex, which ensures the early detection and appropriate treatment of clinical manifestations that may arise during the course of the patient's life.

Indexed as

behaviorbrain tumorneuroimagingpediatricseizurestuberous sclerosis complex

Identifiers

PMID28856172
PMCPMC5570115

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.